Researches on morphine. Pt. 1 / by S.B. Schryver and and Frederic H. Lees.

  • Schryver, S. B. (Samuel Barnett), 1869-1929.
Date:
[1900]
Catalogue details

Licence: In copyright

Credit: Researches on morphine. Pt. 1 / by S.B. Schryver and and Frederic H. Lees. Source: Wellcome Collection.

    17/20 (page 1038)
    numbers when its specific rotation in methyl alcoholic solution was determined. aD = - 3°0', 1=1 dcm., c 2*292, [a]o°= -130-9°. The colour reactions of isomorphine are similar to those of morphine. lsomorphine Methiodide.—4*2 grams of isomorphine and 5 grams of methyl iodide were dissolved in 150 c.c. of methyl alcohol and the mixture boiled on a water-bath. After about 20 minutes, the methiodide commenced to separate. The boiling was continued for 1 hour, at the end of which time the crystals of the methiodide were filtered off. A further small quantity was obtained from the mother liquors. After drying at 80°, the substance was found to melt with some decomposition at 276°. It is soluble in hot water, from which it separates on cooling in the form of white, glistening needles. It dissolves readily in 25 per cent, caustic soda solution. 0*3980 required 9*35 c.c. A/10 AgN03 solution. 1 = 30*0. Cl7H1903N,CH3I requires 1 = 30*6 per cent. A determination of the specific rotation in water gave the following results : aD= - 1°38', 1 = 1 dcm., c= 1*696, [a]2D3°= -91*5°. Morphine methiodide melts at nearly the same temperature as the isomorphine derivative. A determination of its specific rotation in water gave the following result: aD= -0°51', 1=1 dcm., c= 1*162, [a]g°= -72*9°. Action of Acetic Anhydride on Isomoiphine Methiodide.—Four grams of isomorphine methiodide were suspended in 40 grams of acetic anhy¬ dride, to this was added \ gram fused sodium acetate, and the whole boiled on a sand-bath until solution was effected, when 1*6 grams of silver acetate (1 mol.) were introduced. Immediate precipitation of silver iodide occurred, and the mixture was boiled in an oil-bath for 6 hours. Silver iodide was then filtered off, and the filtrate heated in a sealed tube for 3 hours at 180°. The acetic anhydride was then distilled off at 170° in an oil-bath, and the concentrated, light brown solution poured into twice its volume of water. A small quantity of a brown oil separated, which quickly solidified, and was collected, powdered, and dried. The crude substance only amounted to 0’3 gram. This was dissolved in glacial acetic acid, the solution boiled with 1 animal charcoal, and filtered. On cooling, the filtrate deposited small, ; glistening needles, which were collected and found to melt at 154—155°. They were then recrystallised from a large quantity of dry ether, i from which they separated in small, white needles melting at 158—158*5°. O. Fischer and Vongerichten obtained an acetyl di-