Researches on morphine. Pt. 1 / by S.B. Schryver and and Frederic H. Lees.

  • Schryver, S. B. (Samuel Barnett), 1869-1929.
Date:
[1900]
Catalogue details

Licence: In copyright

Credit: Researches on morphine. Pt. 1 / by S.B. Schryver and and Frederic H. Lees. Source: Wellcome Collection.

    18/20 (page 1039)
    hydroxyphenanthrene from morphine methiodide which melted at 159° (Ber., 1886, 19, 792). The filtrate from the solid product, which contains the main product of the action of acetic anhydride and silver acetate on morphine methiodide, when made alkaline, deposits a base which has not yet been investigated. Further reactions of Isomorphine Methiodide.—2T grams of isomorphine methiodide were dissolved in hot water, and to this an aqueous solu¬ tion of 0*78 gram of silver sulphate was added. The precipitated silver iodide was filtered off, and to the filtrate an aqueous solution of 0*8 gram of crystallised barium hydroxide was added, and the whole boiled. Carbon dioxide was passed through for a short time to pre¬ cipitate the very slight excess of baryta. After filtration from the preci¬ pitated barium sulphate, the strongly alkaline solution was evaporated to a syrup, which, when placed in a vacuum, deposited a mass of fern¬ like crystals. On further evaporation in a vacuum, the crystals dissolved, and a syrup was obtained which, on standing overnight, became a hard, solid mass. This, when powdered and dissolved in methyl alcohol, gave a strongly alkaline solution. Excess of methyl iodide was added, and the mixture allowed to stand for 2 days. At the end of this time, it was still strongly alkaline, and did not become neutral until boiled on a water-bath for 1 hour. The methyl alcohol, with excess of methyl iodide, was evaporated off, leaving a syrup which was dissolved in water, and the solution boiled with animal charcoal, filtered, evaporated on a water-bath to a syrup, and placed in a vacuum over sulphuric acid. The resulting varnish gradually became quite hard, and could be powdered ; it was deli¬ quescent, and almost insoluble in ethyl alcohol, but readily soluble in methyl alcohol or cold water. It did not agree in any of its pro¬ perties with codeine methiodide. 0*3908 required 8*7 c.c. A/10 AgN03. 1 = 28*2. Ci7H18(0CH3)02N,CH3I requires 1 = 28*8 per cent. A determination of the specific rotation in water gave the following result : a = — 2°0', 1=1 dcm., c = 2*074, [a]2D5= -96*4°. Preliminary experiments have been made for the preparation of the acetyl compound, and the results will be communicated in a later paper. Addendum.—Since the communication of the above paper to the Society, Pschorr and Sumuleanu have published their synthesis of morphol {Ber., 1900, 33, 1810), and confirmed the formula assigned to this substance by Vongerichten. The Wellcome Chemical Research Laboratories. RICHARD CLAY AND SONS, LIMITED, LONDON AND BUNGAY