Diseases of the kidneys and of the spleen, hemorrhagic diseases / by H. Senator and M. Litten ; edited, with additions by James B. Herrick ; authorized translation from the German, under the editorial supervison of Alfred Stengel.
- Hermann Senator
- Date:
- 1905
Licence: Public Domain Mark
Credit: Diseases of the kidneys and of the spleen, hemorrhagic diseases / by H. Senator and M. Litten ; edited, with additions by James B. Herrick ; authorized translation from the German, under the editorial supervison of Alfred Stengel. Source: Wellcome Collection.
Provider: This material has been provided by the Francis A. Countway Library of Medicine, through the Medical Heritage Library. The original may be consulted at the Francis A. Countway Library of Medicine, Harvard Medical School.
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![given in a paper by C. E. Simon.^ Weber concludes that Bence-Jones albumosuria is always the result of disease of the bone-marrow, the large number of instances of its association with multiple myeloma being striking. Secondary or metastatic tumors in the bone-marrow appear not to cause it. The association of certain nervous phenomena and the appearance of the Bence-Jones body in the urine has been sev- eral times noted (^cf. Anders and Boston, London Lancet, Jan. 10, 1903). Another interesting observation in connection with this peculiar sub- stance has been made by Coriat,^ who found the Bence-Jones body in the pleuritic effusion from a patient with alcoholism, polyneuritis, delir- ium, tenderness over the ribs, and anemia. The urine failed to show the Bence-Jones albumose.—Ed.] True albumosuria (albumosuria vera) occurs principally when the blood is flooded with albumoses; and the latter substances in turn are due to one of two causes : (1) the abnormal passage of albumoses from the gastro-intestinal tract into the blood—alimentary or enterogenous albumosuria, and (2) the disintegration of cells, particularly of leuko- cytes, in the blood itself, in the parenchyma of the tissues, or in hem- orrhagic and purulent exudates from which the albumoses make their way into the blood—hematogenous and histogenetic albumosuria. 1. Alimentary or enterogenous albumosuria has been observed after the administration of large quantities of artificial foodstuflPs given as substitutes for albuminous food, and usually containing an abundance of albumoses. When an ulcerative process is going on in the digestive tract, Chvostek and Stromayer ^ assert that the ingestion of small quan- tities—from 40 to 60 gm. (say from 1—2 oz.)—of albumose suffice to produce an albumosuria. Hence, if such a test turns out positive and other symptoms are present this would be in favor of the existence of an ulcerative process in the gastro-intestinal canal, although a negative result cannot be regarded as a proof of the contrary. 2. It is probable the term hematogenous or histogenetic albumosuria should be applied to the form which occurs in a great variety of febrile diseases, especially in fibrinous pneumonia, purulent meningitis, empy- ema, and pyemic and other similar processes.* [The albumose in these diseases is l3y some regarded as due to the direct influence of the micro- organism upon the body (cf. Harris, Amer. Jour. Med. Sci., cxi.).—Ed.] L. Krehl and M. Matthes ^ go so far as to assert that the urine of a febrile individual always contains albumose, which disappears as the fever subsides; but the investigations by Finigan in the author's clinic failed to confirm the observation that albumoses occur constantly in the urine of febrile individuals.^ This form of albumose, like the deutero- ^ Observations on the Nature of the Bence-Jones Albumin, Am. Jour. Med. Sci., vol. cxxiii., No. 6, June, 1902. ^ The Occurrence of the Bence-Jones Albumin in a Pleuritic Effusion, Am. Jour- Med. Set., vol. cxxvi.. No. 4, Oct., 1903. 3 Wien. klin. WocL, 1896, No. 47. * S. Robitschek, Zeits. f. klin. Med., xxiv., p. 566; Stadelmann, loc. cit.; H. Senator, Deutsch. Med. WocL, 1895, No. 14; Br. Leick, ibid., No. 2. Ito, loc. cit. * Deutsch. Arch./, klin. Med., liv., p. 501. ® Diss, inaug., Berlin, 1902.](https://iiif.wellcomecollection.org/image/b21167886_0030.jp2/full/800%2C/0/default.jpg)
