Two monographs on malaria and the parasites of malarial fevers / I. Marchiafava and Bignami, II. Mannaberg.

  • New Sydenham Society
Date:
1894
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Licence: Public Domain Mark

Credit: Two monographs on malaria and the parasites of malarial fevers / I. Marchiafava and Bignami, II. Mannaberg. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

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    of full doses of quinine. In this case an enormous number of parasites had invaded the vascular system of all the organs, and the young forms without pigment were chiefly met with. We have preserved in the Pathologico-anatomical Institute specimens of malarial brains, in which the capillaries are filled with parasites without any trace of melanosis, [4] Pac/e 56. In several cases of pernicious fever observed during the present year (1893) conjointly by Dr. Bastianelli and ourselves in the Santo Spirito Hospital, forms of segmentation with a great number of spores up to twenty, thirty, or even more, were noticeable. Indeed, in one case the capillaries of the brain presented various types of sporulation with many spores, whilst the spleen and the bone marrow demonstrated, in prevailing numbers, forms of endoglobular division with ten to twelve spores. [5] Page 57. In this description of the amoeba of the summer tertian, as well as in the preceding ones, regarding the other varieties of malarial parasites we have always treated of the endoglobular development of the parasites, without discussing whether or not they are really endoglobular, or simply attached to the red blood-corpuscles. As is well known, Laveran thought the parasites were either free in the plasma or simply attached to the red corpuscles. Marchiafava and Celli, in calling special attention to the younger forms (unpigmented amosbge), maintained that they were found within the blood-corpuscle. To sustain their view they affii-med that the pseudopodia of the amoeba never extended beyond the limits of the red corpuscle, which must have occurred were the parasite merely attached to it. Furthermore they noted that in slowly moving the fine adjustment they were never able to observe the parasite either above or under the corpuscle, but that it always appeared within its substance. Later observers, in studying the parasites of malaria, have never doubted their endoglobular position. It is only recently that Mannaberg has again brought up this question. He believes he is able to demonstrate that the adult forms, the spherical variety belonging to the semilunar, and the larger forms of the tertian type, are endoglobular. In fact, the best proof of this is obtained by watching under the microscope that on the exit of the parasite from the corpuscle the latter becomes decolourised and splits up.