Two monographs on malaria and the parasites of malarial fevers / I. Marchiafava and Bignami, II. Mannaberg.

  • New Sydenham Society
Date:
1894
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Licence: Public Domain Mark

Credit: Two monographs on malaria and the parasites of malarial fevers / I. Marchiafava and Bignami, II. Mannaberg. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

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    of spore formation, though so much effort has been expended in the search for it. My own efforts also in this direction have been in vain. There was much opposition to this view, especially since Marchia- fava and Celli have given their view, explaining the spore formation of Canalis to be degenerative segmentation. While the authors so far mentioned are agreed on the single point that the crescents originate from the small amoeboid para- sites, which on their part may fall directly into spores (they are described under their special heading as pigmented and unpig- mented quotidian parasites, and as malignant tertian parasites), Grassi and Feletti [86] consider that tliis is not tbe case, but that the crescents originate from the amoeboid parasites which are not capable of direct spore formation, but can only form crescentic bodies. They are, indeed, not to be distinguished morphologically from the amoeboid bodies above mentioned, though they are to be regarded, together with tlie crescent series, as a distinct genus. Grassi and Feletti distinguished this genus by the name La,verania, and the species of it appear- ing in man specially as Laverania malarise} I now turn to my own investigations. This short sketch, shows sufficiently that the views concerning the origin, import- ance, and fate of the crescentic bodies are diametrically opposed to those of Laveran, and that further information concerning them is needed. From Laveran, Marchiafava, and Celli it is already known that several of the small amoeboid unpigmented or slightly pigmented parasites are frequently found in a blood-corpuscle. Two or three of these parasites are very often seen lying in one blood-corpuscle, sometimes even five or six of them (see Plate IV, figs. 24, 26). They may occupy the blood-corpuscle either separated from one another, which is by far the most usual condition, or, as I have observed, two, or more rarely three, of the parasites may lie closely adhering to one another (see Plate IV, figs. 27—32). In fresh blood these conglomerate parasites, consisting of two to four specimens, cannot be recog- nised as such, for in these preparations one takes them to be large but single parasites, and it is only in properly stained pre- parations that the structural relations and the conditions of the bodies are cleared up. For in them we recognise clearly two nuclei, two nucleoli, and the protoplasmic bodies lying close ' The following pages, as far as Chapter IV, are taken from a lecture which I [87] gave at the XI Congress fur innere Medicin in Leipzig in 1892. 19