Two monographs on malaria and the parasites of malarial fevers / I. Marchiafava and Bignami, II. Mannaberg.

  • New Sydenham Society
Date:
1894
Catalogue details

Licence: Public Domain Mark

Credit: Two monographs on malaria and the parasites of malarial fevers / I. Marchiafava and Bignami, II. Mannaberg. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

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    fever, all five inoculated individuals suffered from quartan fever; from four tertian sources, twice tertian, once quotidian, and once mixed (tertian and quotidian alternating) resulted; from five quotidian cases, three times quotidian, once tertian, and once a mixed type (quotidian and tertian) occurred ; and from three cases with crescentic bodies, irregular types resulted three times. It is clear from these results that the quartan and irregular types have always given the expected results; varying results have been obtained by inoculations from quotidian and tertian fevers. These variations we shall at once recognise as only apparent when*we see that the three quotidian cases from which Bein [loi] inoculated had tertian parasites, that they were therefore really double tertians, the most frequently occurring combination ; in the one inoculation (No. 13) the inoculated individual received into his blood two generations, and there consequently followed the quotidian type ; in the second case (No. 14), in consequence of the inoculation one generation was evidently destroyed, and therefore only a tertian fever was produced. The third case with a mixed type (first tertian, then quotidian), is to be explained by the fact that the one generation was becoming enervated. In like manner the results from the two cases of tertian fever (Nos. 5 and 12) are to be understood. If Bein, by his experiments, intended to upset Golgi's laws, he • has therefore completely failed, and has indeed only confirmed them by further proofs. Only if he from a pure quartan could have produced a pure tertian, or vice versa, would the result have been fatal to Golgi's theory.^ Beings error is all the more strange because Golgi has repeatedly and precisely published his views on the subject of the relation of the quotidian to the tertian as well as to the quartan. Bein would certainly not have fallen into this error if he had accurately investigated the number of the generations in the blood of the patients. In this respect the history of his patients is unfortunately without any information. From the results and experiments here discussed, we may draw the conclusion that between the types of fever and the species of parasites an indisputable relation exists ; it is especially striking that the quartan fever is always caused by the quartan parasite, the tertian fever most frequently by Golgi's tertian parasite. The quotidian and the regular fevers, as well as certain details concerning their relative bearings, will be considered at length subsequently. ' Such a result from an inoculation has, up to the present, not been forth- coming.