Principles of surgery / By N. Senn ... Illustrated with 109 wood-engravings.
- Nicholas Senn
- Date:
- 1890
Licence: Public Domain Mark
Credit: Principles of surgery / By N. Senn ... Illustrated with 109 wood-engravings. Source: Wellcome Collection.
Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.
613/670 page 593
![fuund ill glanderous nodules; the epithelioid cells are derivatives of con- nective tissue and endothelial cells; while the leucocytes escape from the inflamed capillary vessels. Baumgarten constantly observed karyokinetic figures in the epithelioid cells. The leucocytes that enter the nodule soon show evidences of frag- mentation, and are converted into pus-corpuscles. The bacilli are dis- tributed among the cellular elements singly, in pairs, and in groups. Some of them may be seen also within tlie cellular elements, especiallj'^ the epithelioid cells. Field-mice proved a great deal more susceptible to the virus of glanders tlian guinea-pigs, as they usually died three or four da^'S after inoculation. The necropsy in these niiimals showed, at the point of inoculation, an infiltration from which swollen Ij'inphatic vessels led to the nearest lymphatic glands. In the spleen and liver, which were always found greatly enlarged, numerous small nodules could be seen, while the remaining internal organs presented a normal appearance. Glanders in guinea-pigs and field-mice presents a series of pathological changes that cannot be mistaken for any other aftection. The bacilli of glanders in the different organs can be detected most readily in recent specimens. In the blood bacilli were detected onl3' in very acute cases,—a circum- stance that explains wh}' so man}' inoculations with the blood of glan- derous horses proved unsuccessful. The bacilli of glanders are evidently strictly tissue- and not blood- parasites. Lundgren took a nodule from the lungs of a horse that had died of glanders, and implanted fragments of it under the skin of rabbits. The animals died about the nineteenth da}' after inoculation, and the necropsy revealed induration and small abscesses at the point of infection, and small, yellow nodules in the spleen, liver, lungs, testicles, and mucous membrane of the nose. Implantation of spleen-tissue into other rabbits fi^ed the period of incubation in this animal at from eleven to twelve days. Kranzfeld has recently published the results he obtained by inocula- tions with the virus of glanders in an animal hitherto not subjected to experimentation of this kind. He procured a pure culture from a nodule of a man who had died of glanders after a brief illness. Inoculations were made in a small rodent which is veiy numerous in the southern ])art of Russia, the Spermophilus guttatus. The course of the disease in this animal was almost the same as in the field-mice that were used by Loffler. Of 28 animals infected with different cultures, 16 died on the fourth day, 9 on the fifth, 2 on the seventh, and 1 on the tenth. The post-mortem appearances were always characteristic : a greenish-gray infiltration at the point of inoculation and a number of nodules in the 38](https://iiif.wellcomecollection.org/image/b21207501_0613.jp2/full/800%2C/0/default.jpg)
