Researches on the nature and action of Indian and African arrow-poison / by Hermann Beigel.

  • Hermann Heinrich Beigel
Date:
1868
Catalogue details

Licence: Public Domain Mark

Credit: Researches on the nature and action of Indian and African arrow-poison / by Hermann Beigel. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    10/38 page 334
    Kolliker^, Pelilcan^, Brown-Sdquard, Eckhard*, Funke^, KiiJme^, Pfluger\ and others*. But all these experiments were made on animals ; Tiercelin and Benedict seem to have been the first who applied Curare as a therapeutical agent for epilepsy, but, for want of Curare, were obliged to give up their task, which was, however, continued by two physicians at Paris, namely, by Drs Voisin and Lionville, who communicated the results of their reseai-ches first to the Socidte de Medicine and afterwards to the Academy of Paris'. The symptoms arising from the effects of Urari, according to these authors, range in two different degrees of intensity, the one to be observed after doses of from 5—9 centifirrams. and consisting of defect of sight, heaviness of the eyelids, and sensation of oppression on the frontal region, the other occurring after doses of from 10—135 centigrams, and consisting of Diplopia, dilatation of pupils, heaviness in the head, somnolence and faintings. The symptoms of the first order may exist conjointly or follow each other. During about thirty minutes after injection their course is progressive, then they decrease, and the action of the poison lasts for about one hour and a half, after which it ceases without leaving any sequoias what- ever. The largest dose applied by these authors was 135 centi- grams. After 10 centigrams the symptoms just described appear more rapidly and in a more intense degree; their dura- tion extends likewise over a longer period. They generally make their appearance after sixteen minutes when 10 centi- grams have been taken, and after 12—13 minutes on doses of 11—12 centigrams; duration, from 2—12 hours, and after 1 Vircliow's Archiv, Vol. x. p. 3. 2 Ibid. Vol. XI. p. 401. 3 Experimental Researches, 1853, p. 38. * Beitrage zur Anatomie und Physiolocjie. Hft. I. p. 47. s Beitrage zur Kenntniss des Urari. Bericht der Jidnigl. Sdclis. GeseUsch. der Wissensch. 1859, p. 1. Ueber Pfeilgift. Monatsher. der Berliner Akadem. der Wissensch. 1860. ^ Untersiichungen iiber den Electrotovu?, p. 29. 8 Haber, Ueber die Wu'luuig des Curare aiif das Cerebrospiual systems. Archiv filr Anat. und Physiol. 1859, p. 58. Wiener Pressc 1866.'No. 32 et 33. 10 Gaz. des hopit. 1866. 109 et 111.
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