Immune sera : a concise exposition of our present knowledge concerning the constitution and mode of action of antitoxins, agglutinins, hæmolysins, bacteriolysins, precipitins, cytotoxins, and opsonins / by Dr. Charles Frederick Bolduan.
- Charles Bolduan
- Date:
- 1908
Licence: In copyright
Credit: Immune sera : a concise exposition of our present knowledge concerning the constitution and mode of action of antitoxins, agglutinins, hæmolysins, bacteriolysins, precipitins, cytotoxins, and opsonins / by Dr. Charles Frederick Bolduan. Source: Wellcome Collection.
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![nate somewhat related organisms, though not, usually, to so high a degree. In other words, while agglutinins may be nearly, if not quite, specific in their action, a serum which produces agglutination may be far from being so. The following examples will illustrate the point. In a case of infection with paratyphoid bcicilli, type B, the bacilli of the infecting type B were agglutinated 1:5700; typhoid bacilli, however, only i:i2o, while paratyphoid bacilli type A were not agglutinated at all. In a case of typhoid infection an agglutination with a dilution of 1:40 was obtained for paratyphoid type B, while typhoid bacilli were agglutinated in a dilution of i: 300 and over. As a rule the agglutination with the infecting agent is by far the strongest, i.e. it proceeds even in high dilu- tions, whereas other bacteria require a stronger concentration. In all this we are dealing with the same phenom- enon which undoubtedly plays a r6le in the agglu- tination with blood of icteric patients, the so-called group agglutination, as it was first termed by Mein- hard Pfaundler.^ The bacteria which are aggluti- nated by one and the same serum need not at all be related in their mor]:)hological or other biolog- ical characteristics, as Pfaundler at first assumed. Conversely, micro-organisms which, because of the ' tiber Gruppenajfglutination und das Vcrhaltcn des Bacte- rium coli bei Typhus, Muench. mod. Wochenschrift, 1899, No. 15.](https://iiif.wellcomecollection.org/image/b28060167_0056.jp2/full/800%2C/0/default.jpg)
