Immune sera : a concise exposition of our present knowledge concerning the constitution and mode of action of antitoxins, agglutinins, hæmolysins, bacteriolysins, precipitins, cytotoxins, and opsonins / by Dr. Charles Frederick Bolduan.
- Charles Bolduan
- Date:
- 1908
Licence: In copyright
Credit: Immune sera : a concise exposition of our present knowledge concerning the constitution and mode of action of antitoxins, agglutinins, hæmolysins, bacteriolysins, precipitins, cytotoxins, and opsonins / by Dr. Charles Frederick Bolduan. Source: Wellcome Collection.
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![colon bacillus, and some protoplasm C, common ])crhaps to some other bacterium. In the case of the colon bacillus, protoplasm D is specific, i.e., possessed only by this bacillus, while B is common to it and the typhoid bacillus, and E common to colon and dysentery bacilli. By immunization with the' typhoid bacillus we would obtain a serum containing agglutinins against protoplasm A, B, and C. By virtue of this the serum would exert some agglutinating power also on colon bacilli. On extracting such a serum with the typhoid bacilli, all the agglutinating power woukl be lost, that for the typhoid bacilli as well as that for the colon. On extracting this serum with the colon bacilli we would remove the agglutinating power for these bacilli, but leave the specific agglu- tinating power on typhoid bacilli. Formation of the Agglutinins According to the Side-Chain Theory— Receptors of First, Second and Third Order. — Ehrlich’s theory as outlined in the preceding chapter offers a ready explanation for the development of these bodies. Certain peculianties of the agglutinins require merely a slight elabora- tion of detail in order to be clearly understood. According to Ehrlich the prime function of the side chains of a cell is to provide for the niitrition of the cell. Obviously the simplest mechanism for this purpose will be a side chain which merely anchors the food molecule, leaving the digestion entirely to](https://iiif.wellcomecollection.org/image/b28060167_0059.jp2/full/800%2C/0/default.jpg)
