The uric acid diathesis : gout, sand and gravel / by F. Levison ; translated from the German, and edited by Lindley Scott.

Date:
1894
Catalogue details

Licence: Public Domain Mark

Credit: The uric acid diathesis : gout, sand and gravel / by F. Levison ; translated from the German, and edited by Lindley Scott. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    two patients affected with splenic pseudo-leucocythienna. In them the amount of uric acid was not abnormally large; on some days it amounted to 1 grm. or still more, but on most occasions the quantity was very low—0 3 to 0'2 ffrm.—or so small that the amount could not be estimated. Certain poisons appear to increase the production ot uric acid. Bartels * observed this in a case of carbon monoxide poisoning, the amount of uric acid excreted being abnormally large during the first three days of the poisoning, but sinking again on the appearance of convalescence. Other poisons also show a similar power. Frankel and Rohmann t induced an increased excretion of uric acid in hens, by depriving them of food, and giving them phosphorus in toxic doses; bvit it has not yet been proved that the same thing takes place in mammalia and human beinsrs. Horbaczewski, moreover, gives examples of different febrile diseases, especially pneumonia, accompanied by leucocytosis and increased secretion of uric acid. Similar conditions prevail in the early stage of carcinoma, especially when the development is rapid, and more par- ticularly in carcinoma of the liver. In one case reported the uric acid varied between 0 9 and 1'5 grms. per diem, and a like proportion is said to be found in commencing cirrhosis of the liver. In cases of severe burns also an abundant secretion of uric acid takes place. A boy of fifteen, who had more than a third of his body covei-ed with burns, gave oft on the third day after the accident 0'97 grin, uric acid; * Beutsrhcs ytrchiv filr Idin. Me:1. ]Jd. i. p. 13. t «S. Horbaczewski. Loc. cit., p. 3G. c 2