Diseases of metabolism and of the blood : animal parasites, toxicology / ed. by Richard C. Cabot ... An authorized translation from "Die deutsche klinik" under the general editorial supervision of Julius L. Salinger, M. D. With one colored plate and fifty-eight illustrations in the text.

Cabot, Richard C. (Richard Clarke), 1868-1939

Date:: 1906

Credit: Diseases of metabolism and of the blood : animal parasites, toxicology / ed. by Richard C. Cabot ... An authorized translation from "Die deutsche klinik" under the general editorial supervision of Julius L. Salinger, M. D. With one colored plate and fifty-eight illustrations in the text. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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$oxidation (0. decomposition and C02 excretion) which characterizes individ- ual pathologic conditions has only heen fulfilled to a slight degree. On the other hand, later researches have furnished proofs that the healthy and the sick differ in the reaction of their organism to influences that increase metab- olism (administration of food, work performed, and the amount of heat given off). To appreciate these differences, the physiology of metabolism must be briefly considered. The increase of the processes of oxidation and of heat production, under the influence of the intake of nourishment, which may be subjectively noted in a certain feeling of warmth, has been directly measured by calorimetry. The factors of the respiratory metabolism have also been indirectly con- trolled. If a dog's food is increased upon three different days to 55 per cent, above its previously determined calory requirement by administering iso- dynamic amounts of albumin, fat and carbohydrates, its elimination of heat upon the albumin day rises 19.7 per cent., upon the fat day 6.8 per cent., and upon the carbohydrate day 10.2 per cent. (Rubner). This coincides exactly with the figures which Magnus-Levy1 obtained in In- numerous analyses of the interchange of gases after the administration of particular foods; he has referred to these in his valuable dissertation on the influence of nourishment upon respiratory metabolism. He also deter- mined that the three principal food products increase C02 excretion and 0, consumption in \fvy different degrees. The proteids again take the first place; they increase the intensity of oxidation from 50 to 60 per cent.: then follow the carbohydrates, after the administration of which the interchange of gases is only increased 35 per cent, above the point reached when the stom- ach is empty ; finally the fats, which, if administered in amounts that do not exceed the normal requirement, scarcely increase the consumption of 0, in man at all, and in the < 1<>.lt increase it only about H> per cent. Investigations in man with a freely chosen diet make the increase of metabolism after a men] mtv apparent. In the firsi four hours after break- fast the 02 intake, in comparison to that in a condition of rest, is increased '.'I. 37, 22 and lit percent.; in the first five hours after the midday meal 36$, 30, 20, L8 and L8 pel- cent., and in the first three hours after the evening meal ■'>'■'>. 31 and is per cent. According to this, the increase of the inter- change I' gases for a whole day. in consequence of the administration of food, amounts to L3 per cent, of the ()_, intake, and l!»',1 per cent, of the ('<)_, excretion. Eösslin found similar figures winch are the basis of Vbitfs investigations in metabolism, and if the body's requirement does nut decidedly exc 1 the intake of nourishment, we are generally right in counting about l<> per cent. as the increase of the oxidation processes due to this cause (Zuntz). That this increase of oxidation is due principally to the increased labor iMagnus-Levy, Ueber < 1 i«■ Grösse <!>■- respiratorischen Stoffwechsels anter dem Einflüsse der Nahrungsaufnahme. Pflüger's Arch., Bd. I\. p. 1.$