The immunity index method method of testing antigenic values / A.T. Glenny and Hilda Waddington.

  • Glenny, A. T.
Date:
[1928?]
Catalogue details

Licence: In copyright

Credit: The immunity index method method of testing antigenic values / A.T. Glenny and Hilda Waddington. Source: Wellcome Collection.

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    a single injection. The secondary stimulus effect of Schick toxin has been confirmed in human immunisation by O’Brien (1926) Kellogg and Stevens (1927) Opitz (1927) and Harries (1927). Controls. The immunity index method is controlled by Schick testing at weekly intervals guinea-pigs that have not received a primary stimulus. Considerable variation occurs in the time taken by such control guinea- Table I. Showing the seasonal variation found in the time taken by normal guinea-pigs to be immunised by iveekly injections of a Schick dose of toxin. Percentage number of guinea-pigs Date of commencement. Number of guinea-pigs. immunised in— 10 15 20 25 weeks. weeks. weeks. weeks. 14th July to 6th October 1925 . 60 28 54 66 94 13th October to 20th April 1926 63 0 21 58 74 11th May to 14th September 1926 35 17 e>l 65 81 5th October to 3rd May 1927 . 49 0 14 41 64 24th May ...... (24) 16 37 75 83 Percentage number of guinea-pigs immune. 100 CHART - 80 - 60 - 40 20 - 0 0 l Showing the rate of production of immunity in groups of guinea-pigs injected with weekly doses of Schick toxin. 10 _i_ 15 _i_ 20 _i_ 25 _i_ pigs to be immunised and there appears to be some seasonal variation depending probably upon the general condition of health at different i times of the year. Guinea-pigs have been immunised to the Schick
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