Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton.
- Charles Creighton
- Date:
- 1881
Licence: Public Domain Mark
Credit: Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![100 iwlit|itive rhait){e« n^tich the iictirMit MlniU of plain luuaruUr that the voao-foniuitive procrtti oMUiiKia a Uf w rhanictt'r. The appriNuh U» a tlilfen'ut kiuil of matrix iLwiue J»jw» not prtibahly exphtin of ilM'lf the extraonlinary 'lemairatiou of the ducoiil plat-eiita from the villoiu Kcmirircle ; in my former |«|»er (p|». &7-I and ftMI), 1 |ioiiite<i out tliat the remarkable invai'ina- tioii of the hlaatodermic memhranr ap{ieared to have the ellWt of delining the dUcoiil fonn of the fimt plarental i^wtln But it ia tin* invaAion of the muacular cuat and the aMM«ciaU'«l ililferenccM of veaMd-fonuation that 1 ant now wdely coliremed with. ** The explanation of the |ieculiar oeeomlarj' plarenta of the guinea-pig U, from one |Mtint uf view, to l>e aought for in the Cart that the th't'iH'r tiaHuea of the uterine wall, from wh<Me hy|M*r]ilaaia it U derived, ililfer in im]Mirtaiit re*|>e<'ta from the ti«»ue« nmn’r Ui the epithelial aurfai'e “ When the decidual hv]>er]da»ia Itegina, tho rouml or apindle^ella of the aulvepithelial titMiie »well up, tiecomiiig hug*** pherical, or cuhieAl eleiiietita with a central nurleua and a htrgi* lone of clear pmUiphudii. Tliey ara found at the aaiiie time to have attached theiiiM-lven mon* di'flnitely to the walla of the |Hirallcl and nulial capillarieo, and the whole auWpithelial tiaane tiecoinea in the moat (djviou» manner a iM'rivoM'uhir tiiMUe (aeo tig. 4 of the former |>a]>er). Thia ttMeue ia, in the nature of thinga, on highly voa> culnriw*d M any tiwue can W. In the aulwer}uent rotirM; of the plarental formation, the |»erivaarular cells aggregate thetuM'Ivtw in rt»ws to l»ecc»me the vnao-fonnntive trncU of a new syntem of vea«ela, «u|M*nHMiing the original capillnrieM; they fonn the wall* of the new veneela, ami, ns the walls of tho new viwsrls, they ndain their whole thicknesa of priiUijiIoMii. It is not nccoMsnry U» n-peat lu*n? the ile«criplin that I have given of thiwv thick* walhal vowels, or of tho S]»ongy protoplasmic sulsitance which replt'senta their terminal exjtansions and which constitutes the hulk of the discoid placenta. The ab«»ve resume will enable me to contrast the procern of new formation in the «U*eper layers. “ Tho same hv]>erplasia that showe<l itaelf first in the layers immislintely Iteneath the epithelium, extends after a time through the whole thickness of the Bul>-ejnthclial stratum, and at length reaches the ctdls of the circular muscular coaU As early as the fifteenth «lay the muscle^rells ore found to he enormously enlargwl, and the somewhat slenilcr stAfT-sha}>e<I nucleus has swollen to an enormous bulk, assuiningnt the same time on oval or sjiherical shA{>e. The degri'c of hy]>erplasia is no less in the deeper strata than in the su]>erficial; an«l, up to a certain point, there is a close n^semblancc Ix-tween the swollen individual cells in the two regions. The line f»f «lcmarcation Udwix-n the sub-epithelial stratum and the muscular stratum continues in the hypoqdastic state much the same as in the resting or relaxe<l condition. In l>oth con«litions, the demarcation is not so much in the change from one shapes or character of cell to another, but by reason of the greater com- ]wctness of the muscle-cells, of the general circular disposition of the stratum, and of the transverse direction of the blood-vessels through it The 8ul>-epithelial tissue readily assumes the character of a rich perivascula](https://iiif.wellcomecollection.org/image/b2226758x_0120.jp2/full/800%2C/0/default.jpg)
