Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton.
- Charles Creighton
- Date:
- 1881
Licence: Public Domain Mark
Credit: Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
120/156 page 108
![lOH llirti rrj(itmT Th« atuiwer to thu will U* {Muily fmiiul in tracing their further (ievelu|ittieiiU It luimt bu a«luiitUM| at the uuUet tlwt they luve not all the oaino <le»tiny. Tliere ia aufticieiit evhlettce tliat Nome of theui l»ecouie exravatoil oo aa to funn |)ortionN of hliMMl-kiimaea, their mHiyiiial nuclei foruiin|{ the wall of the ainua. Two celU Hhowing that tnuuifurma* tion are re|ir\m*iitc«l in fl){. 3; in 6 it ia conceivable tliat the ]N.*culiarly tinted and cioiriMrly ((nuiuhtr |in>to|daani would break U]i into a moaa of re<l bl(MMl-4lioc«. The tniMit uaual a<la|itatiun, however, of the ({iant-cella to Iwcouir voao-funiiativo oelU ia o<iinewiuit tlifferenL The bhaabcluinnel U not uauolly fonned in the centre of one cell, but it ia on intercellular ]>aaHa{{a Uiundeil by the clcMM»'aet nuclei of two ronti|{uoua f(iant'cella. Many of the niultinucleur niooMW liave their nuclei only alou)( one e<lKe or aide, and the nucleated aidea of two auili cello, comiti}{ into niotr ap|MMiition, form the nuclentinl wall* of « blooibveMpl. The lion>nucleaUN| jirotophuni of the cell* then a]t|)rar« to decay. Kollowin|( the rows of nvl bhMMl-c4ir|>uarlea from the dee|a>r otrato, they may lie often oliM>r%'ei| Ui lie in the clefta la<tween the crlU ; oa Utr vaao-fonnativo procem oilvanceo, ouch intercellular clefu U>conie blo(Ml>cluinnela with definite nucleatiNl walla. Two aucli IiIihmI. veoM'la, wiUi dei'idy-ataine*! nuclei, are drawn in the up|>er |«rt of Hk- ih It will be ul«ier%'eil, nloo, tliat the inultinuclmr nutoa Iwdow them haa a <lenae cluater of nuclei on the oiile next Ui the venoel; that cluat4*r or Mw of nuclei liecomea in ita turn the limiting or deAnin^ wall of another bhaKl-chunnel, the new channel liein^t the o]iacc lietween the moixinal row and the in* depeinlent bIo«Ml*veaM'I already meiiliotieil. Thiia the lower aide of the lutU'r wrvea aa a wiJI common to tw-o blood opocea, and ia, in fact, a mere IMirtition in the midat of a common vaariilor tract ** Such voaciilar trocta, nunlc up of a numlicr of ftarallel blcxid-channela having their walla in common, ore very charactcriatic of the ilwper rejjion of Uic Kuinea-pi^a placenta, and ea{x>cially of ita accondary and cotyle- donary portion. One of them ia reprcaentwl in Ajt 4. When it ia followisl npwanla towonla the aurface, it runa into villua-Iike proccaaca auch aa thoae ilrawn in Ajj. ft (under a aomewhnt lower jiower). Theae villaa*likc pro- ceaaca arc taken from tlio aiunicircular mw* that conatitutoa the jieculiar accondary or cotyknlonary placenta. Their maryina and their free extremi- tic* contain cloao-act nuclei, but their interior ia a nearly uniform exjianao of fft^nular pmtoplaam. At the lower end, however, there occur linear mwa of nuclei in ita niidat Theae are the terminationa of the parallel nuclcateil aepta of the vaacular tract alreaily ileacrilied ; the mwa of nuclei come to an end gmilually in the granular pmbiplaam of the villua or coty- ledon. Hlooil ia olao aeen here and there inaide the villua, not contained in deAnitely Iwunded apacea, but rather in the aponge-like pmtoplaamic auliatance “ The contraat lx>tween the vaao-formalive proceaa in the deeper layew and in the more auperiicial ia eaaily atate<l. In the. aurface atrata the large |>erivaaculnr cella become fuacil into vaao-formative cortla, each cell retaining ita individuality up to a particular jxiint In the deeper layers the vaao-](https://iiif.wellcomecollection.org/image/b2226758x_0122.jp2/full/800%2C/0/default.jpg)
