Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton.
- Charles Creighton
- Date:
- 1881
Licence: Public Domain Mark
Credit: Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
122/156 page 110
![cclU; an<l tluit in alao tlu* «l««tiny of tlie in the «lei*jHT Tvjjion, In lioth •ituatiuna the hv|H*r]i|iuia of the liiwue ia fuUuwc<i hy the |iro<lucliiin of new ve*»eli*. It nuiy l»c Mthl thiU the |ire-^xiktin){ vi^nnela are inailM{Uttte to the iiourikhnient of the tjTwttly over-^^iwn tiawue. However that may he, there I* aoon olitn-rveil a |iroe<*M of formation of new ami lai^'er ve«M‘hi throu|{houl the entire n-Klon of hy|irr|ilaaiA. The rella that ((o U» form the new ve**«*la are the hy|«eq)laatir eleiiieiita tlieliUM'Ivvia, ami the |teculiarity of the plat'etital liew foniiatioii ia, that it rotixiNUi aimply aii<i aolely of thirk'Wal|i'>i VekMeU, ami of the »|Min^ or ravemoua protoplaamic liMiun whieh repreai-nU their eapillary territory. The hy|M<qtla«tir rella Itoromo vaao-fomuitive rrlU ; ami tlioae of them Uiat <lo m>t ahare in the vaao> formative pn>ceNa umler^'<» either a chaiii^* into mur4iua>like fluid, or int<i (granular or caMviua detriliu. The decay of the relU in the intervala lietwi'cti the newly fonm«l vaeeiilar tract* ia ohviotia laith in the MU|HTficial layer* and in the deejwr. It tak«-* pUre moat exten»ively in the latter, whirh ia tho n*}{ion of ((iant-rella, and th<-*e multinurlear eletnciiU aro ron«tantly found in variou* *ta|jtw of necro*ia or hn-akin^-up. ** Tlie iriant-rella of the placenta n’ornihle in fomi and (^'eneral chanirtem the ifiant-cella of tulMTi'Iea and other morbid pnalurta, ami they a)i|H*ar to me to fnminh an aIino<a |irrf«Tt phyaicilo^iml ty|te or analogy for iho )mlho- lo^cal Kiaiit-rella. Tlie latter have U*<-n «»n«iderwl hy wrinin writem, whom I aliall prorenl imme<liat)dy to (piote, to lie vaao-fonnative cell*, on the evidence derivwl fn>m the |«tholo^ral ronditiona theiuMdvna. WhateX'cr ]dlyaioIo^iraI analoftr hoa lieen *oU){ht for them, hoa alw'ay* limm looked for in the vaao-fonnative proreaaea of the embryo, and no c/imjdetc rorreajion- ilence haa l»e«'n found therein. Hut the vnao-fomintix'e proceaww in the uterine wall, which reault in the building up of the placenta, are recurring |K>rio<Iiral proci'aaca in the adult, liaving tho matun* tiiuuea for their liaaia. It ia not aurjiriaing, therefore, to find that the comwpondenre with tho jiathological vaao-formntive phenomena i* very much greater. Further, the ilifTerencea lietween the new formation of vcaaeU in the au]NTficiaI and in the deeper atrata of the guinea-pig*a utenia, conw|)oml to certain differcncea lietween one kind of granulation-tiaaiie and another. Hoth in the normal ami in the pothologieal caaea, giMit-eella ap|K*ar to be the imiex of hyper- plaaia aaaociaU><l with feeble or imiH-rfect vnaculnrity “ 1 have given in fig. 7 three cell* ahowing the vaao-fomuitive agency of giant-cell*. The cell a i* from the jieripheral zone of a large c^iaeons tiiWrcle (ao-calIe<l aolitary tuliercle) of the choroid plexus in a case of caseona osteo-myelitia of vertebra*, caseou* or scrofuloua or tuberculous testicle, numerous large tubercles of the pia mater, ami especially of the interior of the ccrelK*llum, and smaller miliary tuliercle* of other places. The brain tulwrcles were opaque and caseous in the centn*, but with a narrow jieripheral zone of tran.slucent or non-caseous tis-sue. In the |ieripheml zone were numerous blood-channels, and it was not difficult to find here and there elong.xted multinuclear masses, such as in the figure, that were obviously on the way to become iwrtions of the vascular channels. The cell h, from a](https://iiif.wellcomecollection.org/image/b2226758x_0124.jp2/full/800%2C/0/default.jpg)
