Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton.
- Charles Creighton
- Date:
- 1881
Licence: Public Domain Mark
Credit: Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![We come next to certain pointe of microaoopic structure. Fi^. 11 and 12, Hate IV., are from the other half of the wed^'e- ahaptnl miwi) drawn in lig. 7, Hate HI., and tig. 18, Hate V., U from the we4lge-shaj>c^ maaa in Caae 3 (tuljerculosia in a child). Figa. 12 and 13, from different caaea, show one of the moat remarkable, and {>erha|M) aUo one of the moat character* Utic microscopic appcaranoea of the disease. The small nodule or ultimate tubercle is surrounded hy an extensive wreath or zone of vesseU, which, in the prefiaratiou, are so distende«l with bloo<l (Mirpumdea, that they stand out very conspicuously. The vessels ace of considerable size, but they have ala’ays the structure of capillaries or of small veins. They are apparently tortuous, and they seem to form a kind of plexus round the tubercle. It is only on the iieriphery of the tulwrcle-con- glomemte tliat snudl tubercles so distinctly isolated and so completely invested with blood-vessels ore found; in the pre- paration that fig. 12 is taken from, there arc a considerable num1)er of them, forming the ]a>riphery of the larger mass. Not only is the small tulwrclc surrounded by a oc»at or caftsulc of blood-vessels, but branches of blo<xl-ve8sels sometimes peuetrat43 its interior. In fig. 12 a blood-vessel may l>o seen running right thniugh the sulMtancc of the tubercle; in one of the tultcrclcs of fig. 11, also, there are indications of blood-vessels in the very heart of the nodule. It is the exception to find vessels going through and through the tubercles; but their outer zone commonly shows tmeses of them. Wherever vessels exist in a tubercle, there the new formation is vigorous; and in the stained preparations, the cells are deeply coloured. The marginal zone of the tubercle, to a greater or less breaxlth, is nearly always made up of such deeply-stained and well- preserved elements, but the non-vasculari.sed centre has under- gone a more or less complete necrosis. The central necrosis of the small tubercle is well seen in the preparation from which fig. 11 is taken. In two of the tubercles there is an extensive necrotic area in the centre, and the necrotic centre has separated from the vigorous periphery by a crack or fissure running round in a somewhat uniform line. This clean separation of the necrosed centre from the vasetdar periphery is an important point in the pathology of the disease. It applies](https://iiif.wellcomecollection.org/image/b2226758x_0072.jp2/full/800%2C/0/default.jpg)
