Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton.
- Charles Creighton
- Date:
- 1881
Licence: Public Domain Mark
Credit: Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![«2 tlio prtvoxifttiii^ cull« of the ('round-sulMtance, or the coniu^tive- liKHue eelU of the part, that have ac<piiretl a eerUiiu invaHtmeut of proUiplaem round the nucleuf), and thereby a certain re- aentblance to epithelial eelU. The close-aet tnai^in of nuclei in the ^iunt'Cell U the hi|*he«t development that it reaches an a I'iuut'cell; hy developing further in the Kaine direction it becomes a portion of a blood-vetael. The {^iuut-cells with margin of nuclei and with protoplasmic centre are usually found in tubercles just int4?mal l4i the zone of blood«vessels, or Ixjtween the vascular |M?ripher)' and the necrotic ctmtre. Thu blissl^vessels are, generally S|H*aking, new formatioua, os in granulation tissue, and the jifiaiitHTells are, as it were, the impt'rfuct developments of them oxUmding more into the int4,*rior of the nodules, aud they are the signs of failure in the complete vascularisatiou of the new* fomual tissue. TImt view of the oflire and significance of giant-cells in tulierculosis is held by Hrodowski, Ziegler, Malassez, Charcot, and others. In fonner pa|H!rs, I showed that the formative prtM’4Ms<!8 in the placenta ufford us an exact physiological tv]>u or |iamdigm f«»r the giant*cellsof tubercles.* The formative process in the placenta is largely that of new bbsMl-vessels and blood- sinuses, and there is no mistaking the part that giant-cells play in that pitjcess. They are found chiefly in the doejKjr strata of the new formation (circular muscular coat of the uterus in the C>uinca-pig),and in those dee|>cr strata the vascularisation appears to j)rocecd more sluggishly or under greater difliculties than in the surface layers of the decidua. Multinuclear tracts or blocks of tiasue, and clusters of smaller multinuclear cells, can l)e seen co-op«Tating in various ways U)wartls the formation of new blofxl-channels. The range of variety in the deei)er layers of the placenta covers all the modifications of giant-cells that are found in tul>ercle8, and affords, in fact, a perfect physiological tyi>e for the latter. The giant-cells of tubercles have no siiecific significance, other than that they indicate the imperfect vascu- larity or difficult vascularisation of the new growth. I have • Cirighton, (1.) “On thr Formttion of the I’laocnU in the Oninea-pig,” Journal of AtuOamy and Physiology, vol. xiL (1878). (2.) “Further Olnwn'ation* on the Formation of the Placenta in the Guinoa-pig.” (3.) “The Phyniological Type of the Giant-cells of Tulwrcles and Granulations,** Tbid., vol. xiii. (1879). I I 1 1](https://iiif.wellcomecollection.org/image/b2226758x_0076.jp2/full/800%2C/0/default.jpg)
