Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton.
- Charles Creighton
- Date:
- 1881
Licence: Public Domain Mark
Credit: Bovine tuberculosis in man : an account of the pathology of suspected cases / by Charles Creighton. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![«4 ! with nmivinul iiuclui uml free prutopIasDiic interior, assoeiatiHl with groups of epitheliaMike cells in the younger tubercles, neem U) me, after examining the^ cases, to characterise a sjiecific form of ilisease, that, when 1 found a now formation in all respects the same in sections of a tuberculous U'sticle, which 1 was using for my class of |iuthological histohig)', 1 felt mucJi dis]toseil to con- clude that the particular tuberculous U«ticle must have come fnnu a case of the communicated Ixiviue disease.* A similar conclusion as to the giant-cells of lx>vine tulH*rculosis may be gathered from the oltseiA'ations of < )rth on the tul>ercular diseast* which he induce<i in rabbits by feeding them with nodules from tuberculous cows.* As Professor Orth gives s]»ecial atten- tion to the microscopic characters of the disease which he inductKl by ex|M>riment, I shall include hen* a brief summary of his ex- )>erinientM, by way of supplement to the observations of (ierlach noticcMl in Chapter III. (p. 23). It is no doubt tnie that Orth does not clearly assert the identity of the induced disease in the rabbit with the original disease in the cow. He points out that the n<Mlules on the pleura were not ixulunculated, nor wert! they joined togirther like strings of {>enrls, in the manner characteristic | of the lx)vine disease. In another place he nmiarks on the vvt niisence of calcification, also a characteristic of the Injvine disease, Hut pedunculated nodules, and nodules strung together like jM‘arls, * an; by no means invariably fouml in the tulwrculous cow, nor is * calcification pn*scnt in every case, and still h;s8 is it the only >4; form of degeneration found in the nodules. Hoth the pendulous ' ' form of the 8t?rou8-ineinbrane nodules and the calcareous degenera- i ' tion appear to de{>end on the age of the new formations. The disease induced by experiment is in every case a more acute | • The teeticle wa* ohuined, along with other organa, from the post-moritm room at Aihlonhrookc'a lioapiul on 15th August 1878. The patient, agwi 26, a navvy, hail DufTenHl for four yean from weakneas in the back (ending in caacoua diacaae of lower doraal and upper lumbar vertebne), which came on immediately after an attack of acarlet fever. The testicles were not observed to enlarge until throe months before he died. The lungs, liver, aideeii, and kidneys oontaine»l tuljcrclea. The bnin contained numerous very large nodules, up to the size of a hazel-nut, both in its substance (cerebellum esj»ccially), and also adhering to the branches of the anterior cerebral and middle cerebral arteries, it is to be observed that the disease was a sequel of scarlet fever. • Orth, “ Exi<erimentellc Unterauchungen Uber Futterungs-tubcrculose,’*—](https://iiif.wellcomecollection.org/image/b2226758x_0078.jp2/full/800%2C/0/default.jpg)
