Clinical chemistry : an account of the analysis of blood, urine, morbid products, etc., with an explanation of some of the chemical changes that occur in the body, in disease.

  • Ralfe, C. H. (Charles Henry), 1842-1896.
Date:
[1883]
Catalogue details

Licence: Public Domain Mark

Credit: Clinical chemistry : an account of the analysis of blood, urine, morbid products, etc., with an explanation of some of the chemical changes that occur in the body, in disease. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    When one of these monntojnic radicals of a dibasic acid replaces the hydrogen of ammonia, a monamide is formed. But, as there is still one atom of replaceable hydrogen attached to the radical, this atom can at any time be replaced by a metal or a hydrocarbon radical, and thus the acid character is not entirely lost. From a dibasic, the acid becomes, in fact, a monobasic one. Acids of this kind are called amic acids. Thus we have Oxomic acid. Silver oxamate. Methyl oxamate. CO^ HO ] CoO., A,0) CO., CH3O ] H ^ N. H ^ N. KVN. hJ HJ HJ (3) Glycollic and lactic acids are examples of acids which are diatomic as to their structure and monobasic as to their properties. Only one of the two typical hydrogen atoms that each contains can be replaced by metals. The diflerence has been indicated in the formulfB given above for the acids by marking the replaceable hydrogen by a plus, and the non-replace- able by a minus, sign. The eflect of this peculiarity is that Uoo monad radicals, one neutral and one acid, can be derived from each acid. These radicals replace one atom of hydrogen in the single molecule of ammonia, just as the monad radicals of dibasic acids do, and monamides are formed ; but these monamides are amic acids if the radical so introduced contain the replaceable atom of hydrogen, or neutral amides if it contain only the non-replaceable atom. Thus from glycollic acid we have Glycollamic Potassivmi Metliyl acid. glycollamate. glycoUamate. C2H2O HO ] anp Ko \ aH,o CH3O ^ H In H In ' H j-N hJ hJ HJ