A report of microscopical and physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham.

Timothy Richards Lewis

Date:: 1872

Credit: A report of microscopical and physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham. Source: Wellcome Collection.

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$[ ^1 ] lie received daring liis period of service to science. The blood was carefully examined but without yielding the slightest evidence of the presence of monads, bacteria orvibriones. ExPEBiMENT XV.—A large healthy young dog was put . ^ under chloroform, and about seven Material used (supernatant , , „ i. j. n ■ t 4f fluid), 96 hours old. drachms of the supernatant iluid oi an evacuation which had been kept Death in 5 hours. for 96 hours injected iuto the right femoral vein. Pive hours subsequent to the operation the dog died somewhat suddenly, having passed about a pint of liquid evacuation just before death. A jpost-mortem examination was performed four hours after death. The body was still abZo°x^*iiX*e\^itFf Sii warm, and there was no rigor fluid in peritoneum; movUs. On Opening the abdomen, a little sanguineous fluid was found in the peritoneal cavity. The outer surface of the intestines was much congested and of a purple color. The stomach was healthy. The mucous surface of the duodenum was normal. The jejunum con- tained reddish-yellow frothy fluid, becoming pink towards the lower extremity; but there were no erosions of the much congestion of some mucous membrane. Towards the Ses!with°ddisTflvS*con- middle of the ileum the contents subltincrofthl uver^ ^^ wcrc of a sanguincous aspect and of fluid consistence, but they became paler towards the lower extremity. In the lower half of the ileum there were patches of extreme congestion corresponding, as a rule, with patches of h^cocephalus clispar. Towards the ileo- coecal valve the intestine appeared to be healthy. The large intestine exhibited a few ecchymosed spots, but was other- wise healthy in appearance. The liver was fatty and showed small clots penetrating its substance. The gall-bladder contained bile. The kidneys were slightly congested, but otherwise normal. The bladder contained about three ounces of clear urine. The pleural cavity contained a little slightly sangui- neous fluid. The lungs were col- Thoracic cavity; reddish n t j. • • i • i j. fluid in pericardial and pieu- lapscd, contamiug vcry Jittlc air; but rai cavities. they wcrc uot congcstcd. The peri- cardium contained about ±wo ounces of fluid similar in ap- pearance to that present in the peritoneal and pleural cavities. The right auricle and ventricle were full of dark colored clot.$