A report of microscopical and physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham.

Timothy Richards Lewis

Date:: 1872

Credit: A report of microscopical and physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham. Source: Wellcome Collection.

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$cells (similar to those occurring in the flocculi of cholera dejecta), together with a few epithelial cells and structureless gelatinous material. Thirteen hours after the operation the dog died, and a post-moj'tem examination M^as made coatTnJtS'thl^m^^SmiS^ immediately. No fluid in peri- beneathwMcTtoee^tkeS toucum, no evidcncc of pcritonitis; was unaffected. mesenteric glands much enlarged : dark pink internally and containing fluid of a similar colour. The small intestines were very pale externally, whereas the mucous surface was of a dark pink colour, being coated with a reddish mucous substance, which on removal showed the epithelial coat unaffected, and the mucous membrane not congested. No further evidence of morbid change could be discovered. Experiment LIX.—Pour drachms of the alvine solu- tion, 96 hours old, as used in the soiSion?96'^]bLou^s*^'oid^ last experiment, were injected into the right femoral vein of a moderate sized dog under chloroform. The dog continued to be very active for some time, and attempted to make its escajDC, and was evidently by no means so much affected as the previous animal. By the next day it appeared to be quite well, and some more decomj)Osing material was introduced into its circulation without producing any effect {vide Exp. XLYII). ExPEiiiMENT LX.—A large healthy dog placed under chloroform, and four drachms of the Material injected, normal i i.' i • j.i x alvine solution, 96 hours old: SOiutlOU USed lU tlie tWO prCVlOUS no effect. . , • ± i i ■ j ji experiments were introduced into the right femoral vein. There was no loss of blood. It con- tinued drowsy for a considerable time, but recovered during the course of the day, and by the fifth day was so far re- covered as to seem fit to undergo another operation (vide Exp.LXIII). Experiment LXI.—A small healthy pariah dog was put Material injected, normal under chloroform, and five drachms S4°Lfiw ko^^s?' '■ of the solution of ordinary foecal mat- ter used in Exp. LVII, &c., now 96 hours old, were injected into the right femoral vein very successfully. The animal died within a few hours, and a post-mortem examination was made.$