Volume 1

The extra pharmacopœia of Martindale and Westcott.

  • William Martindale
Date:
1928-1929
Catalogue details

Licence: Public Domain Mark

Credit: The extra pharmacopœia of Martindale and Westcott. Source: Wellcome Collection.

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    The writer was impressed by the fact that Quinine salts, e.g., ih® Hydrochloride and Acid Hydrochloride, are known to be very badly tolerated at the site of injection. Necrosis often follows, and it seemed possible to obviate these ill-effects by carrying the basic theory an additional step forward. Quinine-Mannitol, described in the Lancet 1-/26, p. 455, resulted. It is dealt with on pp. 732, 733 of this volume. Antimony Potassium Tartrate for bilharzia infection is again dwelt upon. The method is good and safe, but the opinion is expressed that something must be left to skill in technique, and judgment as to suitability of the case. A number of favourable statements are embodied concerning what is now regarded as a standard treatment. No drug, it appears, has so great a parasito¬ tropic action with so little organotropic effect in comparison. Compounds of the nature of Urea-Stibamine have been used in kala-azar. Argentum Proteinieum.—It may obviate confusion by re¬ marking that the U.S.P.X. terms the compound containing some 8% of Silver of the Protargol type Argento-Proteinum Forte (‘ Strong Silver Protein ’), while the name Argento-Proteinum Mite (‘ Mild Silver Protein ’) is adopted for the compound of the Argyrol type with 25% Silver—having regard to their relative therapeutic effects. Arsenium : Organic Arsenic Compounds.—In spite of the general preference for Arsenobenzol, the Cacodylates continue to be in some favour as antisyphilitic remedies. In septicaemia, Sodium Cacody- late, in conjunction with Nucieinic Acid, is advised intramuscularly by Sir Thomas Horder. The compound known under the trade name ‘ Stovarsol,’ allied on broad lines to Atoxyl, has recently been much prescribed in amoebic dysentery, yaws, lambliasis, and in the early treatment of syphilis. There is an instructive literature relative to it (see pp. 192, 193), and its administration in conjunction with an Emetine compound, e.g., in the form of Auremetine, has proved a success with amoebic dysentery carriers in this country. Arsenobenzol.—The manufacture and testing of this and Novarsenobenzol are now subject to control by the Therapeutic Substances Act, 1925, and Regulations, 1927. In syphilis Arseno¬ benzol with Mercury is advised. Recourse is made to Sodium Hyposulphite injections where toxic effects are produced. It may be observed that, although the Deutsches Arzneibuch describes Salvarsan and five Salvarsan ‘Preparations’ (Neosalvarsan, Sodium-Salvarsan, Silver-Salvarsan, Neosilver-Salvarsan, and Sulphoxyl-Salvarsan), in not a single instance is there a recommenda¬ tion by the compilers regarding the dose to be used, or how the drug is to be employed. Tryparsamide.—Accounts of the utility of this compound have been published in various parts of the world, but few papers have appeared here. It is given in large doses intravenously in
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