The toxicity of caffein : an experimental study on different species of animals / By William Salant and J. B. Rieger.

  • Salant, William, 1870-1943.
Date:
1912
Catalogue details

Licence: Public Domain Mark

Credit: The toxicity of caffein : an experimental study on different species of animals / By William Salant and J. B. Rieger. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    liubbit 249. Belgian hare. Weiffhl, 890 grams. Diet, oats. Noveinher 17: I.IW p. in., 14.5 rr 2 por ctMit futfein (325 mg per kilo) administered; 4.30 p. Ml., hyporsouHitiveiiws; 110 oLluT Hyiiiptom.s. November 18: 10 a. in., no Hymptdni.s; nriiu' collected, no reduction; rabbit sur- vived. Series H. The object of these experiments was to (let(!rmine tlio minimum fatal ditse of caffein in the two varieties of rabbits, the white ami the K'li.V- AH of the animals selected were api)roximately of the same weij^ht. liubbit J.i9. Belgian hare, male. Weight, 9.>V5 grams. Diet, outs. November lit: 1 p. m., 17 cc 2 j)er cent callVin (3G3 mg per kilo) adminiHlcrcil ])y mouth, followed by 10 cc of 0.9 j)er cent salt solution. November 20: Urine examined, no sugar found, no symptom noticed at any time after injection. Rabbit'254. Belgian hare, female. Weight, 975 grams. Diet, oats. November 1!): 4.05 p. m., 18 cc 2 per cent callein (3(ji) mg per kilo) administered by mouth, followed by 10 cc of 0.9 per cent salt solution. November 20: 9 a. m., rabbit found dead. Rabbit 267. White. Weight, 1,050 grams. Diet, oats. November 23: 12.10 p. m., IS cc 2 per cent caffein (342 mg per kilo) given by mouth, followed by ISccsalt solution; 1 p. m., increased reflexes, tremors marked but no teta- nus; 1.0)]). m., rabbit stretched on abdomen, posterior exlremiti(!H in extended position and paralyzi'd, soon after clonic spasms set in, which recurred about every minute; 1.1 I p. m., tetanus and death. Aulopsij: Liver showed fatty degeneration; slight in- flammation of stomach and intestines; other organs normal. Rabbit 268. White. Weight 1,1 UO grams. Diet, outs. November 23: 20 cc 2 per cent caffein (3G3 mg per kilo) administered by mouth, fol- lowed by 20 cc salt solution; 1.15 p. m., somewhat hypensensitive; 4.30 p. m., tremors fairly marked, no urine ])assed, about 2 cc of bloody looking urine obtained from blad- der, which contained albumen and a considerable amount of glycogen; rabbit died. Rabbit 419, Belgian hare, male. Weight, 1,600 grams. Diet, oats. September 2(5: 10 a. m., 28 cc 2 per cent caffein (350 mg per kilo) given by mouth; reflexes increased at 4 ]). m.; 6 p. m., reflexes still increased, no other symptoms. September 27: 9 a. m., found dead. Autopsy: Lungs, liver, and kidneys congested; other organs normal. Rabbit 420. Belgian hare, male. Weight, 1,250 grams. Diet, oats. September 2(i: 10 a. m., 22 cc 2 per cent caffein (352 mg per kilo) given by mouth; 11.35 a. m., convulsions; 12 noon, found dead. Autopsy: Liver showed very extensive coccidiosis; no other lesions. Rabbit 421. Belgian hare, male. Weight, 1,485 grams. Diet, oats. Sejitember 2t): 10 a. m., 20 cc 2 per cent caffein (351 mg per kilo) administered by mouth; 4 p. m., reflexes increased; 6 p. m., reflexes as before, no tetanus observed. September 27: 9 a. m., rabbit found dead. Autopsy: Congestion of lungs and kid- neys; liver congested and slightly fatty. Rabbit 424. White^male. Weight, 1,295 grams. Diet, oats. September 2G: 2 p. m., 19 cc 2 per cent caffein (293 mg per kilo) administered by mouth; 4 p. m., reflexes increasetl, no other symptoms; 6 p. m., no change since 4 p. m. September 27: 12 noon, convulsions and death. Autopsy: Congestion of the lungs; no other lesions. Rabbit 4iS. White, male. Weight, 1,205 grams. Diet, oats. September 20: 2 p. m., 18 cc 2 per cent caffein administered by mouth; 4 p. m., reflexes increased, no tetanus; 6 p. m., condition unchanged since 4 p. m. September 27: 9 a. m., found dead. Autopsy: Lungs liver, and kidneys congested; other organs normal. Rabbit 422. White, male. Weight, 1,440 grams. Diet, oats. September 2(j: 2 p. m., 21 cc 2 per cent caffein (291 mg per kilo) given by mouth; reflexes increased at 4 p. m. September 27: 3 p. m., alive, no symptoms; 4 p. m., convulsions with recovery, this was soon followed by a violent attack of tetanus, which lasted about one minute and was succeeded by paralysis; rabbit died at 4.30. Autopsy: Liver slightly congested; a small portion of the intestine showed congestion and edema; other organs normal.