Physiological and pharmacological studies of the ureter ...

  • Lucas, Daniel Ralph.
Date:
1908
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Licence: Public Domain Mark

Credit: Physiological and pharmacological studies of the ureter ... Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    Beprinted from the American Journal of Physiology. Vol. XXII.—July 1, 1908. —No. II. PHYSIOLOGICAL AXD PHARMACOLOGICAL STUDIES OF THE URETER. III.1 By DANIEL R. LUCAS. [From the Laboratory of Biological Chemistry of Columbia University, at the College of Physicians and Surgeons, New Yorh.] CONTENTS. Page I. On transmission of pressure from the bladder to the kidney 245 II. Ureteral pressure 250 III. Ureteral pressure and renal circulation 259 IV. Ureteral pressure and the flow of urine 263 V. biochemical influences on ureteral pressure 266 VI. Summary of general conclusions 277 I. On Transmission of Pressure from the Bladder to the Kidney. Introductory. — It is often said that distention of the bladder seems to cause congestion of the kidneys and, when frequent and long continued, may even be etiological of nephritis. At various times clinicians have asked whether I have noticed regurgitation of urine into the ureter from the bladder. Although I have been unable to find any exception to the state- ment that the so-called uretero-vesicular valve is normally quite competent, such questions as the one mentioned above indicate the existence of some doubt as to whether pressure in the bladder may have an effect on the kidneys by direct transmission through the ureter, or only by indirect nervous influence. Publication of some of my notes regarding this matter may therefore be of interest. Experimental.—My first observation in this connection was made during an investigation of normal ureteral pressure and its rela- tion to the peristaltic movements of the ureter in the dog.2 1 The first paper was published in this journal, 1906, xvii, p. 392; the second t appeared in the New York medical journal, 1907 (August 10). 2 Lucas: Proceedings of the Society for Experimental Biology and Medicine, ],. 6l | also S< i< nee, 1905, xxi, p. 721 ; American medicine, 1905, ix. p. 741; Medical news, 1905, Ixxxvii, p. 87.