The significance of the supra-renal capsules in the action of certain alkaloids / by H.H. Dale and P.P. Laidlaw.

  • Henry Hallett Dale
Date:
[1912]
Catalogue details

Licence: Public Domain Mark

Credit: The significance of the supra-renal capsules in the action of certain alkaloids / by H.H. Dale and P.P. Laidlaw. Source: Wellcome Collection.

    9/30 (page 7)
    circuit. It will be seen that a rise of about 120 mm. of blood-pressure occurs, accompanied by marked relaxation of uterine tone. (2) The uterus of a non-pregnant cat was arranged to record as above. The spinal cord had beeu previously cut at the second vertebra under ether, the brain completely destroyed and artificial respiration applied. Fig. 4 shows the effect of injecting 10 mgms. of “ Lodal.” It will be seen that this causes a small rise of blood-pressure accom¬ panied by pronounced inhibition of the uterus. The supra-renal glands were then excised, and the uterus promptly acquired an intense and persistent tonus, similar to that produced by the hydrastinine group of alkaloids on the isolated uterus. Further injections of 10 and 20 mgms. Fig. 4. Effect of 10 mgms. “ Lodal ” on blood-pressure and uterus of virgin cat. of “ Lodal” had then no trace of inhibitor action (Fig. 5), whereas the inhibitor effect of this alkaloid or hydrastinine can usually be repro¬ duced by repeated injections, if the supra-renal glands are left in situ. A subsequent injection of adrenine produced the usual inhibition. It should be noted that the distance of the uterine tracing from the base¬ line in Fig. 5 is due to adjustment of the lever. The uterus was much more tonic at this stage than at the stage represented in Fig. 4. (3) The blood was collected from both supra-renal veins of a cat under A.C.E. mixture by the method used by Biedl1, Ehrmann, and others. The abdomen being opened, the whole alimentary canal, from the cardiac orifice of the stomach to the lower part of the rectum, was