Derivatives of glyoxaline-or 4(or 5)-formaldehyde and glyoxaline-4(or 5)-carboxylic acid : a new synthesis of histidine / Frank Lee Pyman.

  • Pyman, Frank Lee.
Date:
[1916?]
Catalogue details

Licence: In copyright

Credit: Derivatives of glyoxaline-or 4(or 5)-formaldehyde and glyoxaline-4(or 5)-carboxylic acid : a new synthesis of histidine / Frank Lee Pyman. Source: Wellcome Collection.

    15/16 page 202
    (T., 1912, 101, 541), except that the acid solution was precipitated by the addition of sodium carbonate, when the benzoate separated as an oil which soon crystallised. The crystals melted at 67—68° (corr.), and the same melting point was recorded after the substance had been crystallised from water, when it separated in needles containing water of crystallisation: Found, H20 = 8‘7. C15H1402N4,1 JH20 requires H20 — 8'7 per cent. After crystallisation from ethyl acetate, the substance is obtained anhydrous in the form of warts melting at 120—121° (corr.): Found, C = 63'9 ; H = 5*0; N = 20‘0. C15H1402N4 (282T) requires C = 63'8; H = 5*0; N = 19*9 per cent. The substance is sparingly soluble in cold, but fairly readily so in hot water; readily soluble in alcohol or chloroform, but sparingly so in ether. It dissolves readily in dilute hydrochloric acid. The Wellcome Chemical Research Laboratories, London, E.C. [Received, February 14th, 1916.] PRINTED IN GREAT BRITAIN BY R. CLAY AND SONS, LTD., BRUNSWICK STREET, STAMFORD STREET, S.E., AND BUNGAY, SUFFOLK.
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