Yatren no. 105. Emetren.

Date:
[1923]
Catalogue details

Licence: Public Domain Mark

Credit: Yatren no. 105. Emetren. Source: Wellcome Collection.

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    a new preparation of great value and efficacy in the treatment of amebic dysentery and other disorders of the colon. The treatment of Amebic Dysentery, particularly in its chronic forms, has always presented considerable difficulties, and even the administration of Emetin has given only limited satisfaction. Hence the desire for more efficacious substances, possessing, possibly, a chemo-therapeutic action. A remedy of this kind would be expected to destroy the amcebe, including the cyst form, without, on the other hand, producing irritant effects on the intestinal mucous membrane, which latter, owing to the morbid process, is naturally in a hypersensitive condition. Muehlens discovered that Yatren fulfils these desiderata clinically and that Yatren is for this reason the remedy required for the efficient treatment of amebic dysentery; the preparation had been previously known as a_ substance possessing pronounced bactericidal properties combined with entirely neutral behaviour in regard to the tissues. General notes on Yatren. Yatren is an iodo-oxyquinolin-sulphonic-acid combination (odourless) in which the iodine is firmly bound; nor is iodine split off in the organism. Yatren is easily soluble in water on heating and up to 4% persists in solution after cooling. In the form of a dry powder Yatren can be preserved for a long time. Preparation of a solution &c. Take sterile, distilled water at 80° C. and dissolve Yatren powder No. 105 in the proportion of 1:50 to 1:25. Some CO: escapes under effervescence. The resulting solution, orange-yellow in colour, remains clear if kept at body temperature and its bactericidal power maintains its sterility indefinitely. A Yatren solution must never be boiled in view of the risk of secondary effects due to a liberation of iodine. Contact with iron easily leads to colour reactions, which, although harm- less enough in themselves, may be avoided by the use of glass syringes and nickel cannulae. . Yatren solutions prepared as described and injected either subcutaneously, intravenously or per rectum, never injure the tissues. Herzber g’s investigations © show that Yatren is excreted in the urine undecomposed and, quantitatively, almost entire. Given in pills per os, the preparation is likewise easily tolerated. Amebic dysentery. Muehlens and Menk have, as the result of their experience, laid down the following rules of treatment. (The indications as to os 4 eae
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