The factors which determine the production of intraocular fluid / by E. E. Henderson and E. H. Starling.

  • Henderson, Edward Erskine
Date:
[1906]
Catalogue details

Licence: In copyright

Credit: The factors which determine the production of intraocular fluid / by E. E. Henderson and E. H. Starling. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    aorta a large rise of blood. pressure was produced in this eye, since all the blood had to pass through the one carotid artery in order to get back to the heart. On the other hand, an almost complete anaemia could be produced in the eye by obstruction of the one remaining carotid. We give below the results of one such experiment. Cat, antesthetised with Ether and the A.C.E. Mixture. A small dose of Curare was injected after anaesthesia was complete. The extract of 2 grammes of dried leech heads was injected. Time. B.P. in mm. Hg. Weight of secretion. Weight of solids after drying to a constant weight. Percentage of solids. Rate of flow per minute. 3.50 cannula inserted. grammes. grammes. grammes. 3.51 ]30 0-689 0-009 1 -3 3.56 145 0-252 0-007 2-7 0-05 4.16 120 0-756 0-032 4-2 0-037 4.36 100 0-475 0-021 4-4 0-023 4.56 96 0 -482 0-024 4-9 0-024 Dog. Weight, 7^ kilos. Ansesthetised with the A.C.E. mixture and morphia The extract of 2 grammes of dried leech heads was injected. Both subclavians and vertebrals were tied. Temporary ligature round aorta. Cannula in left eye. B.P. observed in right carotid. Time. B.P.in mm. Hg. Amount of secretion in grammes. Total solids in grammes. Percentage of solids. Rate of flow. Remarks. 3-29 Cannula inserted. Aorta 3-30 unobstructed 110 0-811 0-013 1-5 3-35 110 0-432 0-014 3-2 0-086 3-45 100 0-550 0-027 4-9 0-055 3-55 205 1 -153 0-068 5-9 0-115 Aorta obstructed. Fluid 100 0-627 tinged red. 4-0 0-039 6-2 0-062 Aorta unobstructed. 4-15 198 0-816 0-053 6-6 0-081 Aorta obstructed. It will be seen that in every case a rise of intraocular pressure caused an increase in the amount of fluid secreted. It is impossible, however, to deduce directly from thepe experiments that the intraocular fluid is a transudation. The opening of t.he eye-ball and the consequent diminution of the intraocular pressure to nothing have a serious effect on all the intraocular structures.