Tuberculous abcesses of the brain secondary to tuberculosis of the cæcum / Carl W. Rand.

  • Carl W. Rand
Date:
[1935]
Catalogue details

Licence: In copyright

Credit: Tuberculous abcesses of the brain secondary to tuberculosis of the cæcum / Carl W. Rand. Source: Wellcome Collection.

    4/8 page 4
    Fig. 4. Section of wall of frontal lobe abscess showing inflammatory reaction and connective tissue formation of capsule. No tubercles are present. Haematoxylin and eosin method. X80. “Reticulum stain. This section shows a rather condensed capsule of rather uniform size. There is a slight tendency to a fibrosis of the pyogenic layer, the processes extending from the walls of local blood vessels, which at times seem to be increased in number. There is also an evident in¬ crease in number of blood vessels in some portions of the brain, from which a beginning fibrosis is taking place. Fig. 5. Section of abscess wall right frontal lobe show¬ ing numerous tubercle bacilli scattered through the capsule. Ziehl-Nielsen method. X900. “ Section 3. Gold sublimate method. This method reveals some tendency to a proliferation of the astrocytes, but rather peculiarly at a distance from the wall of the abscess proper. These cells are predominant in a layer just be¬ neath the cortex, while the intervening brain tissue be¬ tween this zone of gliosis and the abscess wall is occupied by a cell which has undergone a degree of regressive change. This differs somewhat from the usual abscess in which an active proliferation of these cells is to be found immediately outside of the connective tissue wall. “CajaVs reduced silver method. This method reveals nothing further of importance. “ Section from margin of tuberculous mass in ccecum. IIcematoxylin and eosin (Fig. 6). The section is taken from the margin of the mass in the caecum so that normal tissue could be found to compare with the abnormal. This is also taken with the purpose in mind of observing transi¬ tional stages of the process. Even in what appears to be normal tissue grossly at the margin of the mass are ob¬ served small tubercles of characteristic structure and con¬ taining typical giant cells. These tubercles are found pre¬ dominantly in the submucous but at times are also observed in the muscular coats as well, particularly in the superficial portions. In the muscle layer and in the subserous tissues are found collections of lymphocytes with small haemor¬ rhages about the blood vessels. As one approaches the in¬ volved area there is a gradual replacement of the normal tissues with tuberculous tissue. The muscle coat is broken up and replaced with fibrous tissue, a reticular tissue, or with typical tubercles, which may be conglomerate. The subserous and epithelial layers are quite abruptly re¬ placed with tuberculous tissue which at first diffusely in¬ vades the normal lymphoid tissue or replaces it with discrete tubercles. The lymphoid tissue becomes less and less conspicuous until finally there remains only small lymphocytic infiltration accompanying the pathological process. The glands seem to terminate quite abruptly for a short space; however, their remains can be identified by Fig. 6. Numerous conglomerate tubercles shown in sub¬ mucous coat of caecum. This process is quite different from that shown in the brain abscess of the frontal lobe. Haema- toxylin and eosin method. X36.
    No text description is available for this image
    No text description is available for this image
    No text description is available for this image