Mediastinal form of lymphadenoma (Hodgkin's disease) with extreme so-called pulmonary hypertrophic osteo-arthropathy / by F. Parkes Weber ; with a report on the histology of the case by J.C.G. Ledingham.
- Frederick Parkes Weber
- Date:
- 1909
Licence: In copyright
Credit: Mediastinal form of lymphadenoma (Hodgkin's disease) with extreme so-called pulmonary hypertrophic osteo-arthropathy / by F. Parkes Weber ; with a report on the histology of the case by J.C.G. Ledingham. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![(7) The Secondary Hypertrophic Osteo-arthropathy.—In this connexion I have little further to add, excepting again to point out that the case was a typical one of what Dr. H. E. Syines-Thompson [18] terms the “ diaphysial ” (or “ osteopathy ”) type of hypertrophic osteoarthropathy. The joints appeared very little affected. Probably they were hardly affected at all, but we had not the opportunity of examining them after death. An interesting point is that it was the oedema of the extremities (doubtless more or less connected with the osteo-arthro- pathy) which first called the patient’s attention to the fact that anything was wrong with her, and thus led to the discovery of the intrathoracic disease. She had had no dyspnoea, cough, haemoptysis, or expectoration. In conclusion, I have to express my great indebtedness to Dr. Ledingham for his report on the histology and the blood-films, and to Dr. Finzi for his Eontgen-ray examination and skiagrams of the case. I have also to thank Dr. Chapuis, one of the house physicians at the German Hospital, for kind assistance in the various examinations, and Mr. Hillen, the dispenser, for analysis of the milky fluid from the pleura. REFERENCES. [1] Andbewes, P. W. “ Discussion on Lymphadenoma,” Trans. Path. Soc. Land., 1902, liii, p. 305. [2] Benda, C. “ Zur Histologic der pseudoleukamischen Geschwiilste,” Verhandl. der Deutsch. path. Gesellsch., Berl., May, 1904 (published at Jena, 1904, p. 123). [Compare.] [3] Christian, H. A. “Diseases of the Mediastinum,” in “Osier and McCrae’s System of Medicine,” Lond., 1908, iii, p. 895. [4] Dedbet, P. “ Production experimentale d’un lymphaddnome ganglionnaire generalisd chez un chien,” Comptes rendus de I’Acad. des Sci., Par., 1895, cxx., p. 1373. [5] Gowers, Sir W. R. “Reynolds’s System of Medicine,” Lond., 1879, v, p. 306. [6] Hare, H. A. “The Pathology, Clinical History, and Diagnosis of Affections of the Mediastinum,” Philad., 1889, pp. 107-115. [7] Kidd, P. S., and Turnbull, H. M. “A Contribution to the Histogenesis of Hodgkin’s Disease,” Archiv. Path. Inst. Lond. Hasp., 1908, ii, pp. 130-155. [8] Longcope, W. T. “On the Pathological Histology of Hodgkin’s Disease,” Bull. Ayer Clin. Lab. Pennsylv. Hasp., October, 1903, No. 1, p. 4. 9] Idem. “Notes on Experimental Inoculations of Monkeys with Glands from Cases of Hodgkin’s Disease,” Bull. Ayer Clin. Lab. Pennsylv. Hasp., 1907, No. 4, pp. 18-21. [10] Idem. Bull. Ayer Clin. Lab. Pennsylv. Hasp., 1906, No. 3, p. 86. (See also 0. H. P. Pepper regarding general eosiuophilia in Hodgkin’s disease, ibid, 1907, No. 4, p. 22.)](https://iiif.wellcomecollection.org/image/b2241941x_0024.jp2/full/800%2C/0/default.jpg)
