Reactions : a selection of organic chemical preparations important to pharmacy in regard to their behavior to commonly used reagents / by F.A. Flückiger ; translated, rev. and enl. by J.B. Nagelvoort.
- Friedrich August Flückiger
- Date:
- 1893
Licence: Public Domain Mark
Credit: Reactions : a selection of organic chemical preparations important to pharmacy in regard to their behavior to commonly used reagents / by F.A. Flückiger ; translated, rev. and enl. by J.B. Nagelvoort. Source: Wellcome Collection.
165/192 page 137
![Strychnin solution; neither has cinchonin or quinin any effect. Morphin obscnres the reaction in the following proportions: A solution of 0.00001 g. Strychnin, evaporated with a solution of 0.001 g. morphin sulfate, on a water batli, yields a blurred, Strychnin reaction, when the residue is dissolved in Sulfuric. acid (Reagent 21) and a crystal of KMnO4 added. But still there is evidence whereby to suspect the presence of Strychnin. A solution of 0.002 g. morphin sulfate, treated in like manner with 0. 00001 g. Strychnin, yields like results. A solution of 0.003 g. morphin sulfate, evaporated to dryness, with a solution of 0.00001 g. Strychnin, yielded results in the KMnO4 test, the same as if no Strychnin was present. A solution of 0.001 g. morphin sulfate, treated as above, with a solution of 0.0001 (1:10000) g. Strychnin, offered positive proof of the presence of the latter. Brucin can be destroyed in a mixture of Strychnin and Brucin, by warming it for one-half hour with nitric acid of 1.056 sp. gr., to 50°.—Compare Brucin, “(f)”, page 23. Afevv drops of the fluid, when yellow, give Strychnin reactions with Reagents 22 and 23. —Or brucin and Strychnin, when both present as a result of a verification (examination) of a fluid extract, or of a tincture of Semina Strychni can be precipitated as picrates; and the brucin can be destroyed in the mixture of the picrates.* Quantitative experiments by wrriter [J. B. N•]: Strychnin taken:— Strychnin found:— 0.028 0.026 ,0.032 0.023 0.034 0.032 0.0225 0.0332 Brucin taken: — 0.021 0.032 0.016 0.068 Strychnin and Brucin mixed: — 0.050 + 0.050 0.1 + 0.096 Brucin found: — None. None. None. None. Strychnin found:— 0.054 0.086 * Gerock's process. Compare Archiv der Pharmacie, 1889, page 158. For a critique of this process. by J. B. Nagelvoort, see Proceedings of the Amer. Pharm. Assn. for 1893.](https://iiif.wellcomecollection.org/image/b28107007_0165.jp2/full/800%2C/0/default.jpg)
