Reactions : a selection of organic chemical preparations important to pharmacy in regard to their behavior to commonly used reagents / by F.A. Flückiger ; translated, rev. and enl. by J.B. Nagelvoort.
- Friedrich August Flückiger
- Date:
- 1893
Licence: Public Domain Mark
Credit: Reactions : a selection of organic chemical preparations important to pharmacy in regard to their behavior to commonly used reagents / by F.A. Flückiger ; translated, rev. and enl. by J.B. Nagelvoort. Source: Wellcome Collection.
172/192 page 144
![Thebain. C19 H21 NO3 or C17 H15 NO (OCH3)2 A crystalline powder, melting at 193° to a brown-red fluid, re- crystallizing when allowed to cool. It has a faint alkaline reaction when laid upon red litmus paper moistened with water; this reaction is sharper and appears sooner, if the alkaloid is moistened with alcohol. Is easily soluble in alcohol (94 per cent.), Chloroform and carbon disulfid at the normal temperature; less soluble in ether; yields well- formed crystals from a carbon disulfid solution. Small crystals form in the filtrate, by cooling, when 0.20 g. Thebain has beeil boiled for a wliile with five hundred (500) c. c. of water [one-half liter], renewing the water that evaporates. This watery solution does not affect litmus paper, but has a bitter taste. (a) Thebain is sensitive in this dilution to Reagents 2, 6, 7, 12, 16 and 24; but not to Reagent 17; it is nearly insoluble in cold water. (b) It colors chlorin w^ater (Reagent 3) red, when it is moistened with a small quantity of the Reagent; this red color fades to yellow when more of the Reagent is used. (c) On nitric acid (Reagent 15) it gives a yellow color reaction. (d) On sulfuric acid (Reagent 21) a permanent bright red color reaction. (e) On hydrochloric acid (Reagent 5) it gives a greenish-yellow color reaction. (f) The blue color which morphin gives with ammonium molyb- date and sulfuric acid—see Morphin, page 75—is brown, when Thebain is treated, as described for morphin, and when bbmuth subnitrate, titanic acid or tungstic acid is used; changing to green with the molybdate. A lilac color is obtained here as there. (g) Thebain does not give a blue precipitate with the mixture of potassium ferricyanid and ferric chlorid as Morphin does—see page 76, “(g)”; in course of a few hours the reaction takes place, however, and sooner in direct sunlight. 00 Thebain does not liberate iodin from potassium iodate (KIO:!) like Morphin does under the conditions described’ page 77. (i) Small crystals of Thebanin hydrochlorid form in the yellow fluid in course of a few hours, if 0.20 g. Thebain [or Thebain hy-](https://iiif.wellcomecollection.org/image/b28107007_0172.jp2/full/800%2C/0/default.jpg)
