Reactions : a selection of organic chemical preparations important to pharmacy in regard to their behavior to commonly used reagents / by F.A. Flückiger ; translated, rev. and enl. by J.B. Nagelvoort.
- Friedrich August Flückiger
- Date:
- 1893
Licence: Public Domain Mark
Credit: Reactions : a selection of organic chemical preparations important to pharmacy in regard to their behavior to commonly used reagents / by F.A. Flückiger ; translated, rev. and enl. by J.B. Nagelvoort. Source: Wellcome Collection.
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![twice diluted solution (“B”) held in the anterior part of the mouth for one (1) minute, then rejected and the mouth rinsed, gives usually, in from five (5) to fifteen (15) minutes a characteristic tingling Sensation to the tongue, or on the lips with some.* (1:250,000.) The Sensation of Aconitin, the physiological test on the epithe- lium of tongue or lips, suggests a feeling of having been burned; the solution is too strong when a tingling is feit. When no Sensa- tion is obtained, repeat the experiment with a less dilute solution (“B”), taking five (5) c. c. of solution “A” to make “B”. Aconitin has been found to vary in physiological strength as 1:15; 3V, 5; ilOO.'j' All these preparations give the same special and general alkaloidal reactions. The writer [J. B. N.] often found it necessary to dilute 1:400,000 for the above described physiological tests; commercial Aconitin was to me often distinctly bitter in a 1:250,000 dilution. (c) To fi ve (5) c. c. of above described solution “A”, add a few drops of a five (5) per cent. Au CI3 solution, when a voluminous precipitate is obtained. Collect, wash and dry it. Melting point 135°.5. (d) To five (5) c. c. of solution “A” add twenty (20) c. c. of water and a few drops of Reagent 12. This gives no precipitate; an opalescence only. (e) A few drops of a solution of iodin (4) in potassium iodid (8) and water (500 c. c.) gives in dilution “(d)” a voluminous pre- cipitate. Two less important reactions must be mentioned: (f) 0.005 g. Aconitin gives a pink, sometimes a yellowisli-red color reaction, with 0.010 g. Sugar and two (2) drops Sulfuric acid. Only amorpJioua Aconitin; crystallized A. does not give it. Compare Morphin, page 76, and Veratrin, page 152. (g) An identity reaction on Aconitin, in 11. extr. of Aconit-root of good quality, is to be made as follows: Exhaust five (5) c. c. fl. extr.—when made alkaline—with etlier. Evaporate etlier; add 0.5 (|) c. c. water to the residue of evaporation; warm; filter; add a few drops of the filtrate to two (2) c. c. of * This test, known as Squibb’s, was first observed by Dr. Headland (Wormley’s Microchem. of Poisons, pages 628, II, 1885). It is an indefinite method of verifying the strength of Aconitin. A better one is given since by Allen in Ph. J. and Transact., 1891, p. 230. tMededeelingen uit de Apotheek van het Ziekenliuis te Groningen door M. J. Schröder, in Ned. Tydschr. v. Ph. Ch & Tox. Mei 1891, page 152, on Aconitin. Friedländer, Tromms- dorff, Merck, Gehe and others.](https://iiif.wellcomecollection.org/image/b28107007_0031.jp2/full/800%2C/0/default.jpg)
