Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists.

  • Knoll AG (Ludwigshafen am Rhein, Germany)
Date:
[1891]
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Licence: Public Domain Mark

Credit: Diuretin-Knoll as a diuretic : reports on clinical experiments / Knoll & Co., manufacturing chemists. Source: Wellcome Collection.

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    From this behaviour, we must differ from Gram and ascribe to Diuretin, beside the action on the renal epithelium, also an effect upon the cardiac apparatus. In this we are in accord with the results of Hoffmann’s investigations. That the renal action is the greater, cannot be contested, but the sole effect, in the sense of Gram and Schroder, it is not. As to the other diuretics, digitalis ought chiefly to be mentioned. Though, in many cases, digitalis was far inferior to Diuretin in activity, yet we cannot consider the latter as a substitute for the former. If digitalis is of preponderant value as a cardiac, Diuretin proves itself to be preeminent as a diuretic, with a certain action on the heart which is quite suboidinate to that of digitalis. I he same may be said mutatis mutandis of the other diuretics. I-f» in conclusion, we glance once again at the results obtained with diuretin in our clinic, we may sum up by saying, they demonstrate that Diuretin is a diuretic of remarkable value in cardiac dropsy and in chronic nephritis, of less virtue in cirrhosis hepatis and of no effect in Bright’s disease and pleuritis. . Diuretin produces exceedingly few bye-symptoms and the action does not last long after its suspension. I he cases, in which, after fruitlessly trying most diuretics, we must resort to calomel, become gradually fewer and we shall always first ascertain the effect of Diuretin, before taking up the last weapon — the double edged diuretic, calomel. &
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