Creatin and creatinin / by Edward Mellanby.

  • Edward Mellanby
Date:
[1908?]
Catalogue details

Licence: In copyright

Credit: Creatin and creatinin / by Edward Mellanby. Source: Wellcome Collection.

    33/42 page 479
    (4) That the “gland of the mid-gut” of invertebrates has no mor Phol ogical or physiological connection with the liver of vertebrates, and therefore the newly introduced liver might account for the development of creatin in vertebrates. 7. The excretion of creatin and creatinin in pathological CONDITIONS. The phylogenetic and ontogenetic history of creatin suggests that the liver plays a considerable part in its formation. Therefore the excretion of creatinin in people affected with pathological livers was determined to see if any further evidence of this connection could be obtained. It may be stated at this point that in my opinion creatin in muscle and urinary creatinin are intimately related, and the observa¬ tions that injected creatin and creatinin are excreted unchanged, also that these substances cannot be transformed, the one into the other, under autolytic conditions, are not regarded as strong evidence of their independence. Below are recorded the creatin and creatinin excretions of patients suffering from different disorders influencing the liver1: Total creatinin Total Volume excreted creatin of Sex Age per diem excreted urine Remarks A. Cirrhosis of Liver. (1) 3 43 •756 grs. 0 305 C.CS. Ascites. Urine collected immediately after paracentesis. (2) ? 43 •521 0 285 | Oedema in legs. No enlargement of •521 .. — 305 | liver. (3) 3 46 •575 0 710 ] | No enlargement of liver. Albuminuria. •68 0 885 J 1 Ascites. (4) ? 53 •25 0 350 1 ■ Alcoholic Cirrhosis. Ascites. •44 0 650 i . (5) 3 52 •89 •070 grs. 865 Enlarged liver. Ascites and oedema of legs. (6) ? 49 •325 0 350 Ascites. 1 Most of these figures have appeared in a preliminary communication. Proc. Physiol. Soc. p. xxiii (This Journal, xxxvi. 1907). I take this opportunity of thanking Dr Garrod and Mr T. S. Hele, of St Bartho¬ lomew’s Hospital, for assistance in the procuring of material.
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