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Credit: The stereochemistry of hyoscine / by Harold King. Source: Wellcome Collection.
![This value is distinctly less than [a]D + 28'0° observed for ordinary /-hyoscine bromocamphorsulphonate. The product was again recrystallised, but gave the ordinary form of /-hyoscine bromocamphorsulphonate melting at 169—170°. All attempts again to isolate this labile salt from this particular batch of material were unsuccessful. 1 -Hyoscine Bromocamphorsulphonate, m. p. 200°. By resolution of a weakly active hyoscine by </-a-bromo-7r- camphorsulphonic acid (this vol., p. 502), it was shown that the more sparingly soluble salt was e/-hyoscine a-bromo-Tr-camphor - sulphonate, and that from the mother liquors a deliquescent salt having a specific rotation approximating to that of a /-hyoscine <Aa-bromo-7r-camphorsulphonate could be isolated. The final mother liquor, on prolonged keeping at a low tempera¬ ture, deposited 1 * 65 grams (1*6 per cent, yield) of a salt crystal¬ lising in rosettes of rectangular leaflets. It was not deliquescent and melted at 199—200° (203—204° corr.). The specific rotation was determined on material dried at 95°. c = l*943; / = 2-dcm.; a+41,7/; [a]D+17'9°. 0T028 gram, dried at 95°, gave 0T994 C02 and 0*0553 H20. C = 52*9; H = 6*0. CtfHaO^CwHjgOiBrS requires C = 52*7; H = 5*9 per cent. 0'1 Gram of this salt was converted into the picrate, which amounted to 0*09 gram and melted at 183 186°. On recrystal¬ lisation, it gave 0*08 gram melting at 185—186°, and when mixed with /-hyoscine picrate, no depression in the melting point was . observed. Wellcome Chemical Research Laboratories, London, E.C. [Received, June 21th, 1919.] PRINTED IN GREAT BRITAIN BY R. CLAY AND SONS, LTD., BRUNSWICK STREET, STAMFORD STREET, S.E. 1, OD BUNGAY, SUFFOLK.](https://iiif.wellcomecollection.org/image/b30622086_0009.jp2/full/800%2C/0/default.jpg)
