The constitution of pseudo-muscarine ("synthetic muscarine") / by A.J. Ewins.

  • Ewins, Arthur James.
Date:
[1914?]
Catalogue details

Licence: In copyright

Credit: The constitution of pseudo-muscarine ("synthetic muscarine") / by A.J. Ewins. Source: Wellcome Collection.

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    0-1043 g. ; 0-0300 g. Pt. Pt = 28-76. 0-1071 g.; 0-0312 g. Pt. Pt = 29-13. 0-1384 g.; 0-0401 g. Pt. Pt = 28’97. *0-1641 g.; 0-1114 g. C02; 0-0654 H20 ; C = 18-5; H = 4 4. 0-1320 g.; 0-0846 g.C02; 0-0475 H20 ; C = 17'5; H = 4-0. *0-1346 g.; 9-0 cc. N2 (moist) at 766 mm. and 11°. N = 8-0. 0-1184 g.; 8-5 ,, ,, 753 ,, 13°. N = 8'38. Calculated for [C5H]302N2]2PtCl6. Pt = 28-93; 0 = 17-80; H = 3-86; N = 8-31. The analysis of this salt for C, H, and N gave some difficulty since NO was readily evolved. Unless special precautions were taken and doubly long reduced copper or silver spirals employed some of the oxides of nitrogen escaped reduction and results were obtained such as those instanced above and marked with an asterisk. In such cases nitrous acid was readily shown to be present in the potash bulbs or nitrometer. The platinichloride was converted into the aurichloride by decomposing the former by means of excess of potassium chloride, evaporating the solution to dryness, extracting with alcohol, evaporating off the alcohol and pre¬ cipitating the concentrated aqueous solution of the residue with an aqueous solution of gold chloride. The aurichloride thus formed was recrystallised from water, in which it is moderately soluble, and was obtained in the form of plates which melted with decomposition at 256° after sintering from about 200°. Analysis : 0-1753 g.; 0-0727 g. Au ; Au = 41-47. Calculated for [C5H]302N2]AuC14. Au = 41-73. Hydrolysis of pseudo-muscarine. 0’4 gram of the platinichloride of pseudo-muscarine was boiled under reflux for 2 hours with 5 cc. of 10 °/0 hydrochloric acid. The solution was then concentrated and on standing there was obtained 0‘07 gram of a platinichloride crystallising in needles and hexagonal pkjtes, melting at 237-238°. Analysis gave the following: 0-0646 g.; 0-0199 g. Pt. Pt = 30*8. Calculated for [C5H14ON]2PtCl6 . Pt = 31-6 per cent. The mother liquors from the platinichloride were decomposed by potassium chloride and the aurichloride of the base obtained as described above. This was moderately soluble in hot water and melted at 261-262°. Analysis: 0-1387 g.; 0-0610 g. Au. Au = 44-0. Calculated for [C5H14ON)AuC14. Au = 44-4 per cent.