The utility of enzymes in malaria / by F.W. Lamballe.

  • Lamballe, F. W.
Date:
1913]
Catalogue details

Licence: Public Domain Mark

Credit: The utility of enzymes in malaria / by F.W. Lamballe. Source: Wellcome Collection.

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    ganisms of malaria reference may be made to: Doflein, F.—‘‘Lehrbuch der Protozoenkunde,” 3te Auflage, Jena, 1911, pp. 774-788. Following him and adopting Plasmodium as the generic name, the two forms dealt with in the following are Laveranta malarie, the organism of malignant tertian malaria, and Plasmodium vivax, that of benign tertian malaria. The method of treatment has been by intramuscu- lar injections of the enzymes, trypsin and amylop- sin. My acknowledgments are due to Messrs. Fair- child Brothers & Foster for the injections employed in the following cases. Both ferments are supplied in glass-ampoules holding about one cubic centi- meter. The injectio trypsini has a digestive value of 1,250 Roberts units and it is the most potent prepa- ration of trypsin made. The injectio amylopsini is of maximum potency and contains 500 Roberts amylolytic units. The preparations are sterile and stable. I have kept some of these ampoules for nine months in Central India without appreciable loss of strength. Before injection the contents of each ampoule should be diluted with normal saline 1in5. Latterly I have found, when using these fer- ments in other diseases, that by using two needles, which should be as fine as possible, the pain, which often follows injections of trypsin, may be avoided. The one needle is used to take up the injection into the syringe, the second one, which in this way has no trypsin upon it, to make the actual injection. My, usual practice is to, take up° the conten of one ampoule of trypsin and of one ampoule of amylopsin in a 10 c.c. syringe, and then fill the syringe with sterile normal saline. This amount I usually give as a single dose. Baetzner,® using the same preparations in surgical tuberculosis, gives his
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