Symmetrical adenomata or nodular hyperplasia of the supra-renal glands, and extreme sclerosis of the aorta and coronary arteries / by F. Parkes Weber.

  • Weber, Frederick Parkes, 1863-1962.
Date:
1906
Catalogue details

Licence: In copyright

Credit: Symmetrical adenomata or nodular hyperplasia of the supra-renal glands, and extreme sclerosis of the aorta and coronary arteries / by F. Parkes Weber. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    hypothesis. Loeh and Grithens (15) found that intravenous injections of pyrocatecliinj which have been shown by Dakin (IG) to cause marked rise in blood-pressure, were quite incapable of producing any vascular lesions in rabbits comparable to those produced by adrenalin. Sturli (10) from his experiments with methylamin-acetopyrocatechin and adrenalin, and Mironescu (22) from his trials with euphthalmin and adrenalin, conclude that experimental athei’oma in rabbits is due to a direct toxic action of the adrenalin on the arterial wall, though the latter observer admits that changes in blood-pressure, due to the adrenalin, may favour the production of the arterial lesions in question. Josue (quoted by Loel) and Githens, 15) found that nicotin, though it causes a rise of blood-pressure, has no effect on the structure of the vessel Avails. L. Braun (11) found that the simultaneous injection of amyl nitrite, though it prevented rise of blood- pressure, did not prevent the occurrence of the adrenalin lesions, but A'on Koranyi and also P. Boveri (21), as already stated, found that iodine hindered their appearance.^ It is interesting to note that, as R. M. Pearce (14) and B. Fischer (4) have slioAvn, Josue’s method of adrenalin injections ])roduces myocardial in addition to arterial disease, and that the myocardial changes thus produced are by no means all secondary to stenosis of the coronary arteries. In about half the number of animals exjAerimented on in Avhich the heart changes were examined severe myocardial lesions were found unaccompanied by arterial disease (I’earce, 14). 'Plie ])ulmonary artery seems never to be affected (4 and 12). Many of the observers luiA^e denied the identity of Josue’s “ experimental atheroma ” with the atheroma of the aorta and large arteries Avhich is frequently found at •post-mortem examina- tions on human beings. AV. Krb, junior (16), and some others (7, 8, 9, 14) of those Avho have repeated Jo.sue^s experiments, believe that artificial atheroma produced by adenalin injections in animals is not analogous to human artei’ial atheroma, but regard it as more nearly resembling the primary calcification of ' For a disciASsion and summary on the physiological action of adi’enalin on unstriped muscular tissue see T. E. Elliott, “The Action of Adrenalin,” ‘ Journal of Physiology,’ Cambridge, 1905, vol. xxxii, pp. 401 to 467. In regard to the connection between experimental atheroma and changes in blood-pressure see also H. Batty Shaw, ' Lancet,’ 1906, vol. i, p. 1459.