Dr. Ballard's report upon an acute specific disease, characterised by a peculiar diarrhoea, epidemic among persons who had partaken of refreshments provided at a sale on the Duke of Portland's estate, at Welbeck, Notts. / [Edward Ballard].

Ballard, Edward, 1820-1897.

Date:: 1881

Credit: Dr. Ballard's report upon an acute specific disease, characterised by a peculiar diarrhoea, epidemic among persons who had partaken of refreshments provided at a sale on the Duke of Portland's estate, at Welbeck, Notts. / [Edward Ballard]. Source: Wellcome Collection.

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$character as in the previous animals. One of them had in addition haemorrhages in the liver and an enlarged spleen. Experiment 14.—Two guinea pigs Were fed and inoculated on August 5. They were killed on August 13, and exhibited the same pneumonia as the previous animals. Experiment 15.—Three white mice were fed and inoculated on August 5. One of these mice remained perfectly well. Two of them died spontaneously on August 6, i.e., after 24 hour3. In both animals both lungs showed very severe pneumonia ; the liver was much congested, and the spleen normal. In the blood were numerous minute bacilli. Experiment 16.—With this blood inoculated, on August 6, two white mice. They did not feed well on August 8 and 9, and were killed on August 10. In both animals both lungs showed very severe pneumonia; the spleen was much congested and large, the liver pale and somewhat enlarged. Neither the blood nor the spleen contained any bacilli. Experiment 17.—Two white mice were inoculated on August 7. They were killed on August 13. One animal had very severe peritonitis ; a large quantity of tenaceous purulent exudation in the peritoneal cavity; pleurtis ; and pneumonia in the apex of both lungs. The spleen of this animal was much enlarged. The second mouse had severe pneumonia of both sides, the spleen slightly enlarged ; slight peritonitis. Experiment 18.—Two guinea pigs were inoculated on August 7. They were killed on August 13. In both animals there was bilateral pneumonia; the spleen was not enlarged, the liver slightly enlarged. Cultivation. After 24 hours cultivation, in the incubator, of material of this ham IV. in the same manner as above-mentioned, fluid was obtained which was injected subcutaneously into— Experiment 19.—Two white mice, on August 6. [It is necessary to mention here that in the microscopic slides that had been kept for 24 hours in the incubator, the growth of the sporules, and in connection with them of the bacillus filaments and bacillus rods, similar to those found in the ham I \r., described and figured previously in Fig. I., was very distinct and abundant.] The two mice were killed on August 10. One of them showed severe pneumonia of both sides, the spleen vras much enlarged, the liver pale and enlarged. In the other mouse there were two or three haemorrhagic patches in each lung ; the spleen was not enlarged. Experiment 20.—Two guinea pigs were inoculated with the same cultivation on August 6. They were not feeding well on August 10, 11, and 12, and were killed on August 13. Both animals had severe pneumonia, very extensive on both sides ; the bronchial glands ■were much enlarged. Peritonitis. The liver was slightly enlarged and shovred on its surface a few white specks. I received also a bottle containing viscera, hardened in spirit, of the man W. W. (Case 1), sent by Mr. Allen. Only part of the kidney was fit for microscopic examination. This organ exhibited severe parenchymatous inflammation, casts being present in most of the urinary tubules of the pyramids. The most interesting appearance, however, was shown by the afferent arterioles and capillaries of the Malpighian corpuscles of the cortex, they being distended and plugged by emboli of beautiful bacilli. See Figures 2 and 3. E. Klein. B. Extract from the Meteorological Register kept at Mansfield, by Mr. Wm. Tytiier, E.M.S. Date. Saturday, June 12 Sunday, „ 13 Monday, „ 14 Tuesday, „ 15 Wednesday,, 16 Thursday, ,, 17 Friday, ,, 18 Saturday, „ 19 Barometer. Readings of Hygrometer. Thermometer, 9 p.m. Morning. Evening. Morning. Evening. In. In. Dry bulb. Wet bulb. Dry bulb. Wet bulb. Max. [Min. 30-027 29-978 47-6° 47*0° 53-4° 49-7° 67-0° 40-0° 29-985 30*023 62-8° 57-4° 58-7° 56-2° 71-6° 44-9° 30-072 30-170 60-4° 57-6° 53-7° 52-4° 62-6° 51-7° 30-129 30-072 50-3° 51-3° 50-8° 50-6° 56 9° 49-9° 30-050 30-201 53-7° 53-7° 54-7° 54-2° 55-8° 50-1° 30-227 30-251 55-2° 55-1° 55-9° 55-2° 69-8° 52-3° 29-941 62-6° 58-6° 54-3° 53-7° 69-2° 46-5° 29-770 29-687 50-5C 50-5° 57*9° 57-6° 68-0° 47-5°$