Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb.

  • Hunter, John W.
Date:
1909
Catalogue details

Licence: In copyright

Credit: Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    fluid, sectioned, and examined microscopically. None of the pieces examined showed a trace of tumor tissue. Some- times the necrotic masses would show at the periphery numer- ous polynuclear leukocytes, and sometimes connective tissue was noted growing into the capsule from the outside. This series of experiments showed that tumor tissue, when trans- planted in this manner, where it was subject to the action of the body juices, but not in direct contact with the tissues of the host, became necrotic and disappeared. Conclusions. 1. Our investigations show, without any doubt, that the interpretation of Sticker, and of Beebe and I'lwing, as to the origin of the sarcoma after transplantation of pieces of tumor, is correct. The examination of the pieces at different periods after transplantation proved that peripheral tumor cells remain alive and multiply very soon after transplantation. This mitotic cell multiplication con- tinues and is the cau.se of the tumor formation. At the end of the first week an infiltrative growth of the tumor cells into the surrounding host tissue begins. At no time does the surrounding host tissue apjiear to participate actively iu the tumor formation. 2. During the second and third weeks after transplantation a resolution of the necrotic centre of the tran.splanted piece takes ])lace. Processes of li(|uefaction aid in the resorption and the necrotic material is supplanted by living tumor tissue, which grows actively into the central part of the trans- planted piece. Similar processes have been described by Loci) after trans{)lantation of the sarcoma in rats. Some facts suggest that the tumor cells themselves may act as phagocytes, taking up and reinoving necrotic debris. 3. 'Pumor material inserted in glass capsules before transplantation becomes necrotic and does not give rise to tumor formation notwithstanding the ready access of body fluids to the transjilanted piece.