Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb.

  • Hunter, John W.
Date:
1909
Catalogue details

Licence: In copyright

Credit: Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    INVESTIGATIONS ] Reprinted from the Unive [edical Bulletin, TH OF THE LYMPHOSARCOMATA IN DOGS. By John W. Hunter, M.D., Geo. M. Laws, M.D., and Leo Loeb, M.D. (From the Laboratory of Experimental Pathology and from the William Pepper Laboratory of Clinical Medicine, University of Pennsylvania.) About eight years ago one of us showed that after a suc- cessful inoculation of a sarcoma of the thyroid of white rats, the peripheral parts of the transplanted cells remain alive and multiply rapidly by mitotic division. The new sarcomata arise in the host through a proliferation of the transplanted tissue. This fact was demonstrated by a methodical study of the transplanted pieces, excised at various periods (from a few hours to several weeks after trans- plantation). Independently, Jensen showed the same process to take place after transplantation of adeno-carcinomata in mice. In regard to the tumors (lymphosarcomata or alveolar sarcomata) found in the genital region of dogs, opinions differ very much as to their mode of formation after trans- plantation. StickeP mentioned that the inoculated tumors originated through a multiplication of the transplanted cells. At early stages after transplantation he found the tumor cells alive, at first without stroma; later connective tissue and * Zeit. f. Krebsforschung, 1906, vol. iv.