Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb.

  • Hunter, John W.
Date:
1909
Catalogue details

Licence: In copyright

Credit: Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    It was separated from the surrounding liost tissue by fibrin or eouuective tissue. No proliferation of the surrounding host tissue could be seen. 0. The piece was removed from Dog No. (i after five days. On one side of the periphery living proliferating tumor cells with many mitoses could be seen. At places around the periphery of the tumor there was connective ti.ssue grow- ing into (he (nmor from the host. At some places we found an alveolar arrangement of the tumor cells. At places there were many polynuclear leukocytes Intermixed with the g'rowiufj cells. 'I'he centre of the (nmor was necrotic, ddiere was absolutely no indication that the connective tissue of the host gav’c rise to the tumor cells. At one place there was a group of proliferated tumor cells which had no connection with the tissue of (he host, being separated from the latter by layers of necrotic tissue and blood. 7. d'he piece was re'.novcd from Dog No. 7 after six days. All of the tumor ti.ssue was necrotic. In the periphery, resting on the connective tissue reticulum, there were in j)laces a few living cells which were ])crhaps tumor cells, but this was not at all certain. At many places between the necrotic tissue and the surrounding tissue there were many polynuclear leukocytes pre.sent, probably indicating bacterial infection. S. The piece was removed from Dog No. S after eleven days. No necrotic material was visible; everywhere living tumor tissue was j)re.sent. 'I'lie tumor cells rested on a connective tissue reticulum leaving the cejitres of the reti- culum meshes vacant. At some places, however, these meshes were filled with tumor cells, giving a solid appear- ance to the tumor structure. In siicli regions a few mito.ses could be seen. 9. The piece was removed from Dog No. 9 after eleven days. The greater part of the centre was necrotic. In the periphery small masses of living tumor cells could be found. Between the latter and the necrotic area there was some dense connective tissue, and between this con- nective tissue and the necrotic area larger cells of an epithe-