Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb.

  • Hunter, John W.
Date:
1909
Catalogue details

Licence: In copyright

Credit: Investigations into the growth of the lymphosarcomata in dogs / by John W. Hunter, Geo. M. Laws and Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    from Dogs Nos. 1, 2, and 3. At this date no tumors were palpable in Dogs Nos. 4, 5, and 6. Dog No. 1. Almost the whole piece consisted of well- preserved living tumor tissue. The tumor was composed of small nodules, the centres of some of which contained necrotic areas. This necrotic material was penetrated at places and replaced by living tumor tissue. Quite a number of mitoses were present. In many places we found large collections of small mononuclear round cells. In this case also the tumor penetrated into surrounding connective tissue. Again we found the tumor in many places bordered by a thick wall of dense connective tissue. The demarca- tion was very sharp. There was no proliferation of the cells of the connective tissue capsule on the side toward the tumor, but on the other side, toward the surrounding tissue, there were some mitoses present and cells proliferating into the surrounding fat. In the capsule the lymph vessels were filled with small round cells (lymphocytes). At places the tumor penetrated into the surrounding fat tissue. The tumor had a distinct infiltrating growth progressing into the connective tissue and separating it into strands. Dog No. 2. No necrosis was found in this piece. The tumor tissue consisted of solid cell masses without cavities. Many mitoses were found, and many capillaries were sur- rounded by masses of round cells, which were distinct from the tumor cells. On one side, the tumor was surrounded by a thick wall of dense connective tissue, which showed no sign of any proliferation. At places the tumor cells penetrated into this capsule and separated the different lamellae of connective tissue. There was no doubt that in this case the tumor growth took place entirely from its own tissue and received no additions from proliferation of the connective tissue. A small vessel was entirely filled with round cells (lymphocytes). (The piece removed from Dog No. 3 was lost.) After twenty-three days Dog No. 2 died, and at this time no tumors were palpable. After forty-one days, in Dog No. 1 two tumors of about