The relation between natural and synthetical glycerylphosphoric acids. Pt. II / by Frank Tutin and A.C.O. Hann.
- Tutin, Frank.
- Date:
- 1906
Licence: Attribution 4.0 International (CC BY 4.0)
Credit: The relation between natural and synthetical glycerylphosphoric acids. Pt. II / by Frank Tutin and A.C.O. Hann. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
12/14 page 1758
![0 2064 of air-dried salt gave 0-4070 C02 and 0-1324 H20. C = 53-8 ; H = 70. 0-1968, dried at 100°, gave 0 4392 C02 and 0-1156 H20. C = 60 9 ; H = 6-5. C49H6iOi4N4P,73^0 requires C = 54-l ; 11 = 6-8 ; H20 = 116 per cent. C49H6iOi4N4P requires C = 61-3 ; H = 6 3 per cent. 02366, dissolved in 25 c.c. of absolute alcohol, gave aD — 32' in a 2-dcm. tube, whence [a]D -28-2°. 0*1607, dissolved in 25 c.c. of water, gave aD — 19' in a 2-dcm. tube, whence [a]D - 24-6°. The brucine salt of the synthetical glycerylphosphoric acid was also prepared by Carr4 (loc. cit.), who assigned to it a formula containing 9 molecules of water, whereas the above results indicate the presence of only 7 molecules. In addition to this, Carre stated the melting point of the salt to be 181°, whereas it has been observed by the present authors to be 158—159°. It was considered possible that these dis- crepancies were due to the fact that Carr6 prepared his brucine salt from the free acid, while the brucine salts described in the present communication were all prepared from the corresponding barium salts by double decomposition. In other words, as the synthetical glyceryl- phosphoric acid appears to be a mixture, and undergoes slow hydrolysis when heated with water, it was thought possible that the free acid used by Carr4 might have become altered in composition on account of its constituents differing in their relative velocities of hydrolysis. The acid was therefore liberated from a quantity of the synthetical barium salt, and boiled with water for two and a half hours. It was then converted into the brucine salt, and the latter crystallised, when it was found to be identical with the preceding preparation. 0-3032, when heated at 100°, lost 0-0354 H20. H20 = 11 *7. C49H61014N4P,7H20 requires H20= 116 per cent. The melting point of the dried salt was the same as previously observed. The authors are therefore unable to confirm the figures given by Carre for the melting point and water of crystallisation of the brucine salt of synthetical glycerylphosphoric acid. The Wellcome Chemical Research Laboratories, London, E.C. . R. CLAY AND SONk* LTD., BREAD ST. HILL, E C., AND BUNGAY, SUFFOLK.](https://iiif.wellcomecollection.org/image/b22425433_0014.jp2/full/800%2C/0/default.jpg)
