Safety testing of new drugs : laboratory predictions and clinical performance / edited by D.R. Laurence, A.E.M. McLean, M. Weatherall.

"Although the number of new drugs introduced into medicine has declined, the proportion casuing alarm has changed very little, throwing doubt on the efficacy of the elaborate and costly test procedures insisted on by government regulatory authorities. Test data submitted usually remain confidential. This boko is unique in presenting case studies on drugs made available by pharmaceutical companies which contain details of the experiments done in animals, predictions made before the substance was administered to man and the outcome in terms of therapeutic benefit and ill-effects. Studies on bethanidine, bromocriptine, cimetidine, practolol and related beta-blocking agents, and tamoxifen are given."--Provided by publisher.