Report on the U.S. pharmacopoeia ; Note on rhubarb, for 1869. Note on collodion / by F.C. Mussgiller. Liquor opii compositus ; by Edward R. Squibb.

  • E. R. Squibb
Date:
1870
Catalogue details

Licence: Public Domain Mark

Credit: Report on the U.S. pharmacopoeia ; Note on rhubarb, for 1869. Note on collodion / by F.C. Mussgiller. Liquor opii compositus ; by Edward R. Squibb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    92/96 page 92
    for opium inultiplictl by 10, and to liiin it appeiirs l)ufh simitle and easy, and lias often been verified by extractions of murpbia on tlie large scale by various processes. Now it is probable tbat tbo average yield of umrpbia from good powdered opium now-a-days will not be over lO-.j to 11 per ct. And tlie officinal tincture, containing 1-25 troyounces or 000 grains of such t)piain to the pint, would therefore contain to grains of morphia to the pint. Hence t)4 grains of morphia to the pint, or 4 grains to the fluidounce, is assumed as the stand- ard of strength of the officinal tinctura opii, or laudanum.* This assumed strength for the officinal tincture has always been used as the standard of strength for liquor opii compositus, and will continue to be so. It is therefore only nccessar}' to divide the number of grains of morphia contained in the remaining sixtcen-seventeentbs of the de])urated solution by 4, in order to obtain the number of fluidounces of oO cc. each, to which the solution must be made up when finished for use. In the supposed case the 182-72, or say 18o grains, divided by 4, gives 4.V7r) fluidounces, or l;)T2 c.c, as the measure for the finished solution. Now if it be desired to make the simple litjuor opii, as suggest- ed on page 73, it is only necessary to add water and alcohol in the ([uantities indicated by the assay, kee|)ing the ]>roportion of alcolnd as small as may be with safety. With one-sixth of its weight of alcohol the preparation would probably keep indefi- nitely, and could then be used by hypodermic injection. When the solution is to be made into liquor opii compositus, the proceeding is less simple. Thirty cubic centimetres or a fluidounce of the preparation, when carefully and accurately made on the basis given on page To, weighs from 28 05 to 21) 00 grammes, or from 446-76 to 448-30 grains, varying to thi.s extent only when made from dif- ferent parcels of pood, and only fair quality powdered opium. Twenty-nine grammes, or four hundred and forty-seven and a * Morphia = 30U) is to crystallized sulphate of morphia (jiS, SOs. 6HO,=379) us 'Mi is to 379 or thereabouts, and therefore 4 grains of morphia is al)oiit ei|uivaleiit to 5 grains of crystallized sulphate of Mior|)hia.
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