Genetic analysis of hereditary diseases with incomplete phenotypic manifestation / K. Eriksson.
- Eriksson, Karl, 1892-
- Date:
- 1954
Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Credit: Genetic analysis of hereditary diseases with incomplete phenotypic manifestation / K. Eriksson. Source: Wellcome Collection.
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![53 If we choose Tables 21 and 24 as examples of the application of the method, the uncorrected value of r (Table 21) is= 0.266 and the corrected value (Table 24)= 0.219. In 2-sib groups (Table 21) the observed number of D sibs is= 9 and the expected number = 7.2-0.266 3.724 l-(l-r)2 1-(1 -0.266)2 0.461 The corresponding values in Table 24 are 11.106 and 9.891 • 2-0.219 4.332 1-(1-0.219)2~0.390~ ■ For all the sib groups the following values and pertinent variances are obtained: <7=1/3.129 = 1.768 (T = l/l.816 = 1.348 The difference between the total of observed and computed values in Table 21 is 0.351 + 1.768. Also in individual sib groups there is no significant difference between observed and computed values. The corrected values in Table 24 show complete agreement with the computed values. Instead of testing the agreement between observed and computed values of the number of D sibs, one can, according to Lenz and Hogben, compute the total number of sibs, N sibs included (the 0 type), within each sib group according to the formula SÍCq-л l-(l-r)' After that one divides the observed number of D sibs by this value and thus obtains the computed value of r which is compared with the corre¬ sponding expected (a priori) r value. The variance is here S¿0-i-(l — r) [1 — (1 —r) —л-г(1 — r)^] л](https://iiif.wellcomecollection.org/image/b18019754_0056.JP2/full/800%2C/0/default.jpg)
