Gout: its pathology and treatment / by Arthur P. Luff.

  • Arthur P. Luff
Date:
1899
Catalogue details

Licence: Public Domain Mark

Credit: Gout: its pathology and treatment / by Arthur P. Luff. Source: Wellcome Collection.

Provider: This material has been provided by Royal College of Physicians, London. The original may be consulted at Royal College of Physicians, London.

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    the kidneys in the production of uric acid and in the development of gout will be dealt with in detail. ESTIMATION OF URIC ACID IN URINE. One of the lines of investigation that I have pur- sued required that a very large number of estima- tions of the total amount of uric acid excreted in the urine per diem should be made. The process that I have emplo3^ed throughout is the Gowland- Hopkins method, which is a very accurate and reliable process. I have had a very considerable practical experience of the various methods that have been emploj^ed for the estimation of uric acid in the urine, including Heintze’s process, Hay craft’s process, Fokker’s process, Salkowski’s process, and Ludwig’s modification of Salkowski’s process. In connection with all these processes there are faults or objections from which the Gowland-Hopkins process is free. This process depends upon the fact that when urine is saturated with ammonium chloride all the uric acid is precipitated as an ammonium urate. From the ammonium urate the uric acid is set free, and the amount of it is determined by titration with a standard solution of ])otassium permanganate. One great advantage of this process is that there is no danger of the reduction of the ammonium urate as there is of the silver urate produced in some of the other processes; moreover, the ammonium urate is easy to filter, and permits of the liberation of its uric acid with ureat